Results 241 to 250 of about 163,246 (289)

Aβ antibodies target not only amyloid plaques but also distinct brain cells and vessels. [PDF]

Alzheimers Dement
Wen G, Lindblom N, Zhan X, Garcia-Ryde M, Deierborg T, Kobro-Flatmoen A, Gouras GK.   +6 more
europepmc   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness. [PDF]

Sci Adv
Hu R, Park J, Qian Y, Xiong S, Elsabbagh AH, Chhikara A, Fan H, Shi Z, Liu L, Li Y, Song Z, Mahmoud AM, Chen J, Baur JA, He Y, Layden BT, Zhou Z, Xu P, Ong SG, Wang Z, Jiang Y.   +20 more
europepmc   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

The estrous cycle moderates the food and body weight suppressive effects of glucagon-like peptide-1 receptor agonism. [PDF]

Diabetes Obes Metab
Applebey SV, Xiao AG, Reiner BC, Hayes MR.   +3 more
europepmc   +1 more source

IL-21 attenuates liver inflammation by enhancing myeloid-derived suppressor cells immunosuppressive function in chronic HBV infection. [PDF]

J Transl Med
Li X, Jin Z, Pan M, Dong Z, Chen J, Liu Z, Chen H, Ye G, Zhong S, He W, Tang L, Rao G, Li Y.   +12 more
europepmc   +1 more source

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam [PDF]

, 2018
Akk, Gustav, Cao, Lily Q, Chakrabarti, Shampuma, Evers, Alex S, Germann, Allison L, Mennerick, Steven, Montana, Michael C, Shin, Daniel J, Wozniak, David F, Yuede, Carla M   +9 more
core   +1 more source

Study of conditions to evaluate light hypersensitivity in a light-dark box using a mouse model and a mydriatic. [PDF]

PCN Rep
Hirota S, Gotoh L, Hayashi R, Kitai Y, Matsuoka H, Masuda M, Kawasaki H, Hori H.   +7 more
europepmc   +1 more source

Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling. [PDF]

Int J Mol Med
Kim JH, Lee SH, Kim SY, Kim JW, Jeong JS, Chung EH, Lee SH, Kim CY, Choi BK, Ko JW, Kim TW.   +10 more
europepmc   +1 more source