Results 21 to 30 of about 111,588 (244)

Comparison of urine proteome among rat models by intraperitoneal injection with single bacteria and co-injection with two bacteria.

PLoS ONE, 2021
PurposeTo explore and compare urine proteome changes among rat models by intraperitoneal injection with single bacteria and co-injection with two bacteria.MethodEscherichia coli and Staphylococcus aureus are two common human pathogens.
Wenshu Meng, Chenyang Zhao, Youhe Gao
doaj   +2 more sources

Effects of ionizing radiation in combination with Erufosine on T98G glioblastoma xenograft tumours: a study in NMRI nu/nu mice

Radiation Oncology, 2012
Background Erufosine is a promising anticancer drug that increases the efficacy of radiotherapy in glioblastoma cell lines in vitro. Moreover, treatment of nude mice with repeated intraperitoneal or subcutaneous injections of Erufosine is well tolerated ...
Henke Guido, Meier Verena, Lindner Lars H, Eibl Hansjörg, Bamberg Michael, Belka Claus, Budach Wilfried, Jendrossek Verena   +7 more
doaj   +1 more source

Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To explore the therapeutic role of morin against L-arginine-induced acute pancreatitis in rats. Methods: The group 1 received two intraperitoneal injections of normal saline, and groups 2-4 were given two intraperitoneal injections of L ...
Kanwal Rehman, Ummara Rashid, Komal Jabeen, Muhammad Sajid Hamid Akash   +3 more
doaj   +1 more source

The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis

Türk Spor ve Egzersiz Dergisi, 2019
The objective of this study was to assessment the effect of melatonin on lipid profile in rats with experimentally induced acute pancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats were used. Group I animals was no applied.
Ercan Keskin, Deniz Uluışık
doaj   +1 more source

Intratesticular versus intraperitoneal Busulfan administration: a comparative study on spermatogenesis suppression in quails and chickens

Poultry Science
: Generation of transgenic birds can be achieved by temporal suppression of endogenous spermatogenesis in males prior to primordial germ cell implantation.
Noor R. Wattad, Eden Ozer, Stefanie Altgilbers, Claudia Klein, Eyal Cohen, Ohad Zuckrman, Eitan Sessler, Tamar Hadad, Yehonatan Alcalay, Uri Abdu   +9 more
doaj   +1 more source

Histhopathological Investigation of the Intraperitoneal Injection of Starch-Graft-Polyaniline/Magnesium Oxide (Chitosan/MgO) Nanocomposites on Liver and Kidney of Rats

مجله دانشکده پزشکی اصفهان, 2019
Background: At the present study, we assessed the effects of intraperitoneal injections of nanocomposite of Starch-Graft-Polyaniline/Magnesium Oxide (Chitosan/MgO) on liver and kidney of male rats. Methods: 28 male rats were randomly allocated into four
Mohammadreza Hajinezhad, Alireza Samzadeh-Kermani   +1 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Can Human Recombinant Epidermal Growth Factor Improve Ischemia and Induce Healing of Anastomosis in an Experimental Study in a Rabbit Model?

Journal of Investigative Surgery, 2017
Purpose: Anastomotic leaks following intestinal operations may cause devastating effects on patients. Ischemia may also occur at the intestinal walls in the presence of strangulations.
Rahman Şenocak, Mustafa Tahir Özer, Şahin Kaymak, Zafer Kılbaş, Armağan Günal, Metin Uyanık, Orhan Kozak   +6 more
doaj   +1 more source

A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice

Journal of Lipid Research, 2010
Here, we report the creation of a single-helix peptide (ATI-5261) that stimulates cellular cholesterol efflux with Km molar efficiency approximating native apolipoproteins.
John K. Bielicki, Haiyan Zhang, Yuan Cortez, Ying Zheng, Vasanthy Narayanaswami, Arti Patel, Jan Johansson, Salman Azhar   +7 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source