Results 21 to 30 of about 153,401 (288)

Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model.

PLoS ONE, 2021
Laboratory animals frequently undergo routine experimental procedures such as handling, restraining and injections. However, as a known source of stress, these procedures potentially impact study outcome and data quality.
Nora Weegh, Eva Zentrich, Dietmar Zechner, Birgitta Struve, Laura Wassermann, Steven Roger Talbot, Simone Kumstel, Miriam Heider, Brigitte Vollmar, André Bleich, Christine Häger   +10 more
doaj   +1 more source

Fatal and non-fatal inflammatory injuries induced by different concentrations of L-arginine in Kunming rats

International Journal of Immunopathology and Pharmacology, 2018
To establish animal models of fatal and non-fatal pancreatitis, we randomly divided 55 Kunming rats into three groups: Group A received three intraperitoneal injections of 8% L-arginine (L-arg); Group B received three intraperitoneal injections of 10% L ...
Chunxia Li, Ge Zhang, Aijun Dai, Xiuyan Wang   +3 more
doaj   +1 more source

EXPRESSION OF PROTEIN GENES PARTICIPATING IN FIBROPLASTIC PROCESSES IN MICE LUNG DURING THE DEVELOPMENT OF TUBERCULOUS INFLAMMATION

Сибирский научный медицинский журнал, 2019
The study analyzes the expression of protein genes involved in intracellular signaling pathways associated with a profibrotic response, activation of epithelial-mesenchymal and endothelial-mesenchymal transitions, in modeling tuberculous granulomatosis ...
P. M. Kozhin, A. V. Chechushkov, N. S. Zaytseva, M. V. Khrapova, L. A. Cherdantseva, E. B. Menshchikova, A. V. Troitsky, V. A. Shkurupy   +7 more
doaj   +1 more source

Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To evaluate the effect of bioflavonoid ternatin (TRT) on rat liver regeneration and oxidative stress after 70% partial hepatectomy (PH). METHODS: Thirty six young male Wistar rats were randomly assigned to two groups of 18 animals each - control
José Ulisses de Souza Melo, Radamés Bezerra Melo, Jefferson Menezes Viana Santos, Manoel Messias Campos Júnior, Sérgio Botelho Guimarães, Paulo Roberto Leitão Vasconcelos   +5 more
doaj   +3 more sources

Intraperitoneal insulin administration in pigs: effect on circulating insulin and glucose levels

BMJ Open Diabetes Research & Care, 2021
Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal insulin boluses. There is a lack
Sven Magnus Carlsen, Ilze Dirnena-Fusini, Marte Kierulf Åm, Anders Lyngvi Fougner, Sverre Christian Christiansen   +4 more
doaj   +1 more source

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage [PDF]

, 2004
BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates.
Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave, Rojiani, Amyn, Rosenthal, Arnon, Subbarao, Sangeetha, Wilcock, Donna M   +6 more
core   +3 more sources

Intraperitoneal injections as an alternative method for micro-CT contrast enhanced detection of murine liver tumors

BioTechniques, 2019
Micro-computed tomography (micro-CT) coupled with tissue, or vascular, specific contrast agent has emerged as a powerful tool for detecting and monitoring tumor growth in the liver of murine animals.
Nathan Sweeney, Stephen Marchant, Jesse D Martinez   +2 more
doaj   +1 more source

Adriamycin-loaded albumin-heparin conjugate microspheres for intraperitoneal chemotherapy [PDF]

, 1994
Adriamycin-loaded albumin-heparin conjugate microspheres (ADR-AHCMS) were evaluated as possible intraperitoneal (i.p.) delivery systems for site-specific cytotoxic action.
Bae, Y.H., Cremers, H.F.M., Cremers, Harry, Feijen, Jan, Kim, S.W., Kwon, G., Lam, K., Los, G., Seymour, L.W., van Vugt, M.   +9 more
core   +3 more sources

Comparison of urine proteome among rat models by intraperitoneal injection with single bacteria and co-injection with two bacteria.

PLoS ONE, 2021
PurposeTo explore and compare urine proteome changes among rat models by intraperitoneal injection with single bacteria and co-injection with two bacteria.MethodEscherichia coli and Staphylococcus aureus are two common human pathogens.
Wenshu Meng, Chenyang Zhao, Youhe Gao
doaj   +2 more sources

Intraperitoneal Injection Is Not Always a Suitable Alternative to Intravenous Injection for Radiotherapy [PDF]

Cancer Biotherapy and Radiopharmaceuticals, 2013
Abstract Intraperitoneal (IP) injection is frequently reported to be as effective as intravenous (IV) injection. Because it allows administering a larger volume with more radioactivity, we have investigated this route and the possibility of using it to circumvent the volume constraint we earlier experienced with pretargeting radiotherapy. Using (99m)Tc
Dou, Shuping, Smith, Miles, Wang, Yuzhen, Rusckowski, Mary, Liu, Guozheng   +4 more
openaire   +4 more sources