Quantitative Prediction of Human Pharmacokinetics for Fc‐Engineered Therapeutic Monoclonal Antibodies With Increased FcRn Binding Mutations After Subcutaneous Injection [PDF]
Clinical and Translational ScienceFc‐engineered antibodies (mAbs) enhancing FcRn binding have rapidly expanded in drug discovery and development. Although an approach exists for predicting the pharmacokinetics of Fc‐engineered mAbs after intravenous injections in humans, no methodology ...
Kenta Haraya, Taichi Kuramochi
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Needle-free Subcision and Hyaluronic Acid Injection Using CureJet for Horizontal Neck Fold Reduction Assessed by Ultrasound and 3-dimensional Analysis [PDF]
Plastic and Reconstructive Surgery, Global OpenBackground:. Horizontal neck folds (HNF) result from fibrous connections between the platysma and skin, often becoming more prominent with aging and skin laxity.
JongSeo Kim, MD
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Comparison of Cholic Acid (MT921) and Deoxycholic Acid (DCA) in Fat Reduction Efficacy and Skin Adverse Reactions in Mini Pigs and Rodent Models [PDF]
PharmaceuticalsBackground/Objectives: This study compared fat reduction efficacy of cholic acid-based formulation (MT921) and deoxycholic acid (DCA), as well as skin adverse reactions (ADR), in mini pigs, mice, and rats.
Sujin Cho +5 more
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Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial [PDF]
Open MedicineThe administration of subcutaneous low molecular weight heparin (LMWH) injections frequently causes injection pain, disrupting the comfort of patients. No studies were found evaluating the effect of the application of local vibration in the management of
Yılmaz Dilek, Güney Bahar Gülşah
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Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics
Advanced Science, 2023 Proteins are among the most common therapeutics for the treatment of diabetes, autoimmune diseases, cancer, and metabolic diseases, among others. Despite their common use, current protein therapies, most of which are injectables, have several limitations.
Alexander M. Curreri +6 more
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The Effects of Trends in Osteoporosis Treatment on the Incidence of Fractures
Journal of Osteoporosis, 2021 Summary. We analyzed the data about the preferences of medication and incidence of fractures between osteoporosis patients from 2012 to 2016. Our results suggested that the number of patients treated with intravenous and subcutaneous injections increased
Akira Horikawa +6 more
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Effect of a reused insulin needle remaining in a patient's body
Journal of Diabetes Investigation, 2023 Diabetes is one of the most common chronic diseases at present, and insulin pen injection therapy plays an important role in the treatment of diabetes.
Yong‐jie Qiao +7 more
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Real-World Analysis of Therapeutic Outcome in Type 1 Diabetes Mellitus at a Tertiary Care Center [PDF]
Diabetes & Metabolism Journal, 2022 Insulin replacement in type 1 diabetes mellitus (T1DM) needs intensified treatment, which can either be performed by multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII).
Antonia Kietaibl +2 more
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Journal of Diabetes Investigation, 2020 To date, almost all case reports of insulin‐derived amyloidosis described the presence of a subcutaneous mass that was observable on physical examination.
Terumasa Nagase +11 more
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Heterogeneous trajectory of depressive symptoms after repeated subcutaneous esketamine injections
Journal of Affective Disorders Reports, 2021 Background: Ketamine is an effective antidepressant with a 65–70% response rate and a fast onset of action. Esketamine (S-ketamine) has been found to be twice as potent as R-ketamine, while inducing fewer adverse effects, such as sedation and cognitive ...
Matheus Ghossain Barbosa +16 more
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