Results 1 to 10 of about 2,173,558 (351)

Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics

Advanced Science, 2023
Proteins are among the most common therapeutics for the treatment of diabetes, autoimmune diseases, cancer, and metabolic diseases, among others. Despite their common use, current protein therapies, most of which are injectables, have several limitations.
Alexander M. Curreri, Jayoung Kim, Michael Dunne, Pavimol Angsantikul, Morgan Goetz, Yongsheng Gao, Samir Mitragotri   +6 more
doaj   +2 more sources

Quantitative Prediction of Human Pharmacokinetics for Fc‐Engineered Therapeutic Monoclonal Antibodies With Increased FcRn Binding Mutations After Subcutaneous Injection [PDF]

Clinical and Translational Science
Fc‐engineered antibodies (mAbs) enhancing FcRn binding have rapidly expanded in drug discovery and development. Although an approach exists for predicting the pharmacokinetics of Fc‐engineered mAbs after intravenous injections in humans, no methodology ...
Kenta Haraya, Taichi Kuramochi
doaj   +2 more sources

Needle-free Subcision and Hyaluronic Acid Injection Using CureJet for Horizontal Neck Fold Reduction Assessed by Ultrasound and 3-dimensional Analysis [PDF]

Plastic and Reconstructive Surgery, Global Open
Background:. Horizontal neck folds (HNF) result from fibrous connections between the platysma and skin, often becoming more prominent with aging and skin laxity.
JongSeo Kim, MD
doaj   +2 more sources

Shock following subcutaneous injections of polymethylmethacrylate [PDF]

Medicina Intensiva (English Edition), 2015
info:eu-repo/semantics ...
Boattini M., Francisco A. R., Cavaco R., Rodrigues J., Bento L.   +4 more
openaire   +6 more sources

Comparison of Cholic Acid (MT921) and Deoxycholic Acid (DCA) in Fat Reduction Efficacy and Skin Adverse Reactions in Mini Pigs and Rodent Models [PDF]

Pharmaceuticals
Background/Objectives: This study compared fat reduction efficacy of cholic acid-based formulation (MT921) and deoxycholic acid (DCA), as well as skin adverse reactions (ADR), in mini pigs, mice, and rats.
Sujin Cho, Deu John M. Cruz, Minhee Shin, Jaeyoon Byun, Junho Lee, Seongsung Kwak   +5 more
doaj   +2 more sources

Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial [PDF]

Open Medicine
The administration of subcutaneous low molecular weight heparin (LMWH) injections frequently causes injection pain, disrupting the comfort of patients. No studies were found evaluating the effect of the application of local vibration in the management of
Yılmaz Dilek, Güney Bahar Gülşah
doaj   +2 more sources

Cutaneous complications following extra-articular corticosteroid injections: A prospective cohort study [PDF]

Science Progress
Background Local corticosteroid injections are widely used in the management of musculoskeletal conditions; however, the incidence and timeline of associated cutaneous complications, such as hypopigmentation and subcutaneous fat atrophy, remain poorly ...
Aryeh Weinstein, Konstantyn Drizlikh, Nimrod Rozen, David Rothem, Guy Rubin   +4 more
doaj   +2 more sources

Best infection control practices for intradermal, subcutaneous, and intramuscular needle injections

Bulletin of the World Health Organization, 2003
OBJECTIVE: To draw up evidence-based guidelines to make injections safer. METHODS: A development group summarized evidence-based best practices for preventing injection-associated infections in resource-limited settings.
Hutin Yvan, Hauri Anja, Chiarello Linda, Catlin Mary, Stilwell Barbara, Ghebrehiwet Tesfamicael, Garner Julia   +6 more
doaj   +2 more sources

The Effects of Trends in Osteoporosis Treatment on the Incidence of Fractures

Journal of Osteoporosis, 2021
Summary. We analyzed the data about the preferences of medication and incidence of fractures between osteoporosis patients from 2012 to 2016. Our results suggested that the number of patients treated with intravenous and subcutaneous injections increased
Akira Horikawa, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Yoichi Shimada, Hiroyuki Kodama, Akihisa Sano   +6 more
doaj   +1 more source

Tumescent Injections in Subcutaneous Pig Tissue Disperse Fluids Volumetrically and Maintain Elevated Local Concentrations of Additives for Several Hours, Suggesting a Treatment for Drug Resistant Wounds. [PDF]

, 2020
PurposeBolus injection of fluid into subcutaneous tissue results in accumulation of fluid at the injection site. The fluid does not form a pool. Rather, the injection pressure forces the interstitial matrix to expand to accommodate the excess fluid in ...
Dunn, James CY, Huynh, Nhan, Koulakis, John P, Putterman, Seth, Rouch, Joshua, Wu, Holden H   +5 more
core   +2 more sources