Results 71 to 80 of about 2,173,558 (351)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ОСОБЕННОСТИ НЕВРОЛОГИЧЕСКИХ ПРОЯВЛЕНИЙ САХАРНОГО ДИАБЕТА 1-го ТИПА ПРИ ИСПОЛЬЗОВАНИИ РАЗНЫХ МЕТОДОВ ИНСУЛИНОТЕРАПИИ

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015
The study aimed to examine the features of neurological manifestations of diabetes mellitus type 1 by using insulin therapy with continuous subcutaneous infusion and multiple subcutaneous injections.

doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

What Should Being to Prevent of Pain, Ecchymosis and Hematoma in Subcutaneous Heparin Injections?

Florence Nightingale Journal of Nursing, 2019
Today, subcutaneous heparin injections are commonly used for a variety of treatments. After the subcutaneous heparin injections, ecchymosis, hematoma occurence and pain are the most common complications.
Gülçin AVŞAR, Mağfiret KAŞIKÇI
doaj  

The Relationship of a Combination of Human Adipose Tissue-Derived Stem Cells and Frozen Fat with the Survival Rate of Transplanted Fat

Archives of Plastic Surgery, 2015
Background The survival rate of grafted fat is difficult to predict, and repeated procedures are frequently required. In this study, the effects of the freezing period of harvested adipose tissue and the addition of human adipose tissue-derived stem ...
Ki-Young Ha, Hojin Park, Seung-Ha Park, Byung-Il Lee, Yi-Hwa Ji, Tae-Yeon Kim, Eul-Sik Yoon   +6 more
doaj   +1 more source

Clinical Evaluation of an Investigational 5 mL Wearable Injector in Healthy Human Subjects

Clinical and Translational Science, 2021
An investigational wearable injector (WI), the BD Libertas Wearable Injector (BD Libertas is a trademark of Becton, Dickinson and Company), was evaluated in an early feasibility clinical study for functional performance, tissue effects, subject ...
Wendy D. Woodley, Wen Yue, Didier R. Morel, Audrey Lainesse, Ronald J. Pettis, Natasha G. Bolick   +5 more
doaj   +1 more source

Fremanezumab for the Preventive Treatment of Chronic Migraine. [PDF]

, 2017
BACKGROUND: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP), is being investigated as a preventive treatment for migraine.
Aycardi, Ernesto, Bigal, Marcelo E., Blankenbiller, Tricia, Dodick, David W., Goadsby, Peter J., Grozinski-Wolff, Melissa, Ma, Yuju, Silberstein, Stephen D., Yang, Ronghua, Yeung, Paul P.   +9 more
core   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Análise da lipoenxertia estruturada na redefinição do contorno facial

Revista Brasileira de Cirurgia Plástica
INTRODUÇÃO: A enxertia de gordura como preenchimento no rejuvenescimento e melhoria do contorno facial vem sendo usada por alguns autores e demonstra um potencial excelente como método de escolha para essa finalidade, uma vez que tem como premissa o ...
Marco Túlio Junqueira Amarante
doaj   +1 more source

A phase 1 randomized study of hemodynamic effects and pharmacokinetic interactions during concomitant use of rimegepant and sumatriptan in healthy adults

Cephalalgia Reports, 2021
Objective: This randomized, partially-blinded, placebo-controlled study evaluated hemodynamic effects, pharmacokinetic interactions, and safety of concomitant administration of oral rimegepant and subcutaneous sumatriptan.
Robert Croop, Andrea Ivans, Matt S Anderson, Joseph Stringfellow, Richard Bertz, Michael Hanna, Francine Healy, David A Stock, Vladimir Coric, Richard B Lipton   +9 more
doaj   +1 more source