Results 81 to 90 of about 139,649 (304)

Clinical Evaluation of an Investigational 5 mL Wearable Injector in Healthy Human Subjects

open access: yesClinical and Translational Science, 2021
An investigational wearable injector (WI), the BD Libertas Wearable Injector (BD Libertas is a trademark of Becton, Dickinson and Company), was evaluated in an early feasibility clinical study for functional performance, tissue effects, subject ...
Wendy D. Woodley   +5 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

Patients with rheumatic diseases and their conceptions of regular self-administered subcutaneous anti-TNF injections [PDF]

open access: yes, 2010
Background: Pain, stiffness and functional restrictions of the joints are the main problems for patients with inflammatory rheumatic diseases. When conventional drugs fail to delay the development of the disease the patient may require biological ...
Arvidsson, Barbro,   +3 more
core  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan   +5 more
wiley   +1 more source

A phase 1 randomized study of hemodynamic effects and pharmacokinetic interactions during concomitant use of rimegepant and sumatriptan in healthy adults

open access: yesCephalalgia Reports, 2021
Objective: This randomized, partially-blinded, placebo-controlled study evaluated hemodynamic effects, pharmacokinetic interactions, and safety of concomitant administration of oral rimegepant and subcutaneous sumatriptan.
Robert Croop   +9 more
doaj   +1 more source

Variable Stiffness Flexure Structures Enabled by Phase‐Change Gallium and Adhesive Interfacial Locking for Soft Robotic Applications

open access: yesAdvanced Engineering Materials, EarlyView.
A flexure‐based variable stiffness structure is developed by integrating phase‐change modulation and adhesive interfacial locking of gallium. The design enables a wide stiffness variability, transitioning from soft, flexible behavior to rigid, load‐supporting performance.
Sungjin Kim   +2 more
wiley   +1 more source

Effectiveness of Vibration in Reducing Pain and Improving Satisfaction During Subcutaneous Injections: A Randomized Crossover Clinical Trial [PDF]

open access: yes
Çiriş Yıldız, Cennet/0000-0002-1351-5439; Yildirim, Dilek/0000-0002-6228-0007;AimThe pain experienced during and after the injection may cause discomfort and lead individuals to develop a negative perception toward future injections.
Kugu, Emre   +2 more
core   +1 more source

Large fat and skin necroses after deep subcutaneous injections of a slow-release somatostatin analogue in a woman with acromegaly. [PDF]

open access: yes, 2010
OBJECTIVE: Somatostatin analogues are the most commonly used drugs for treatment of acromegaly. Known side effects include gastrointestinal reactions, cholelithiasis, effects on glucose metabolism, and mild reactions at injection sites.
Besjakov, Jan   +5 more
core   +3 more sources

Subcutaneous injection of insecticide for attempted suicide: a report of two cases

open access: yesActa Orthopaedica et Traumatologica Turcica, 2020
We present two patients (30-year-old female, and 20-year-old male) who attempted suicide by injecting commercially available insecticides into the forearm. No systemic signs of intoxication were observed during the acute and subacute periods.
Atakan Aydin, Funda Akoz, Metin Erer
doaj  

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