Results 41 to 50 of about 724,211 (317)

Current Trends for Treating Lateral Epicondylitis [PDF]

Clinics in Shoulder and Elbow, 2019
Lateral epicondylitis, also known as ‘tennis elbow’, is a degenerative rather than inflammatory tendinopathy, causing chronic recalcitrant pain in elbow joints.
Gyeong Min Kim, Seung Jin Yoo, Sungwook Choi, Yong-Geun Park   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparative Clinical Effectiveness of Management Strategies for Sciatica: Systematic Review and Network Meta-Analyses [PDF]

, 2013
Background There are numerous treatment approaches for sciatica. Previous systematic reviews have not compared all these strategies together. Purpose To compare the clinical effectiveness of different treatment strategies for sciatica simultaneously.
Rickard, I, Din, N.U., Ud Din, Nafees, Lewis, Ruth, Nafees Ud Din, Phillips, C.J., Phillips, CJ, Williams, N.H., Deborah Fitzsimmons, Nefyn H. Williams, Ruth A. Lewis, Lewis, R, Phillips, Ceri J., Hendry, Maggie, Burton, K., Williams, Nefyn H, Hendry, M., Din, N, Maggie Hendry, Ceri J. Phillips, Hendry, M, Fitzsimmons, Deborah, Nafees, S, Sutton, A., Fitzsimmons, D., Matar, Hosam E., Ceri Phillips, Rickard, Ian, Rickard, I., Ian Rickard, Alex J. Sutton, Matar, H.E., Kim Burton, Wilkinson, C., Sutton, A.J., Hosam E. Matar, Burton, A. Kim, Sadia Nafees, Clare Wilkinson, Lewis, R.A., Nafees, S., Williams, Nefyn, Burton, Anthony, Matar, HE, Fitzsimmons, D, Wilkinson, Clare, Sutton, Alex, Nafees, Sadia   +47 more
core   +1 more source

An unfortunate injection [PDF]

BMJ Case Reports, 2016
Intramuscular injection has been used to administer medications for more than a hundred years. However, despite our profession's long experience with intramuscular administration, preventable complications such as injection nerve palsies are still prevalent in developing countries. Injections account for one-fifth of all traumatic nerve injuries. These
Bhavik Sandip Shah, Chase Yarbrough, Amy Price, Rakesh Biswas   +3 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evidence to Use Botulinum Toxin Injections in Tension-Type Headache Management: A Systematic Review

Toxins, 2017
Tension-type headache (TTH) is the most common type of chronic recurring head pain. It can occur twice as often in women as in men. It is the most common type of headache. Its lifetime prevalence is 30% to 78% in the general population.
Mieszko Wieckiewicz, Natalia Grychowska, Marek Zietek, Gniewko Wieckiewicz, Joanna Smardz   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Association of Anti-VEGF Injections with Progression of Geographic Atrophy

, 2016
Age-related macular degeneration (AMD) is one of the leading causes of blindness in developed countries in people over the age of 60 years. One of the forms of advanced AMD is wet AMD.
Sravanthi Vegunta, Sai Bhuvanagiri, Ryan Enslow, Benjamin Cutler, Brian Stagg, Michael Neff   +5 more
core   +1 more source

Exploring Intra-Articular Administration of Monoclonal Antibodies as a Novel Approach to Osteoarthritis Treatment: A Systematic Review

Biomedicines
Biological drugs, including monoclonal antibodies, represent a revolutionary strategy in all fields of medicine, offering promising results even in the treatment of osteoarthritis (OA).
Amarildo Smakaj, Elena Gasbarra, Tommaso Cardelli, Chiara Salvati, Roberto Bonanni, Ida Cariati, Riccardo Iundusi, Umberto Tarantino   +7 more
doaj   +1 more source