Results 61 to 70 of about 631,722 (269)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Acta Orthopaedica et Traumatologica Turcica, 2020 Objectives: We compared the short-term results of anti-inflammatory drugs alone or in combination with local injection of a corticosteroid and anesthetic mixture in the treatment of tennis elbow.\r\nMethods: The study included 21 patients (12 males, 9 ...
Serdar Toker +4 more
doaj
Pharmaceutical Care in Ontario
Journal of Medical Science, 2020 Pharmaceutical care is an integral part of global healthcare. Indeed, pharmacists are recognised as a primary point of care, providing many services to optimise the patient’s healthcare.
Jacqueline Dzionek
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2007 Injectivity of objects with respect to a set $\ch$ of morphisms is an important concept of algebra, model theory and homotopy theory. Here we study the logic of injectivity consequences of $\ch$, by which we understand morphisms $h$ such that injectivity with respect to $\ch$ implies injectivity with respect to $h$.
Adamek, J., Hebert, M., Sousa, L.
openaire +3 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
AğrıObjectives: The purpose of this study was to evaluate the safety and efficacy of autologous fat tissue injection into the knee joint for the treatment of osteoarthritis.
Derya Bayram +2 more
doaj +1 more source