Results 81 to 90 of about 772,174 (280)

Comparative Clinical Effectiveness of Management Strategies for Sciatica: Systematic Review and Network Meta-Analyses [PDF]

, 2013
Background There are numerous treatment approaches for sciatica. Previous systematic reviews have not compared all these strategies together. Purpose To compare the clinical effectiveness of different treatment strategies for sciatica simultaneously.
Rickard, I, Din, N.U., Ud Din, Nafees, Lewis, Ruth, Nafees Ud Din, Phillips, C.J., Phillips, CJ, Williams, N.H., Deborah Fitzsimmons, Nefyn H. Williams, Ruth A. Lewis, Lewis, R, Phillips, Ceri J., Hendry, Maggie, Burton, K., Williams, Nefyn H, Hendry, M., Din, N, Maggie Hendry, Ceri J. Phillips, Hendry, M, Fitzsimmons, Deborah, Nafees, S, Sutton, A., Fitzsimmons, D., Matar, Hosam E., Ceri Phillips, Rickard, Ian, Rickard, I., Ian Rickard, Alex J. Sutton, Matar, H.E., Kim Burton, Wilkinson, C., Sutton, A.J., Hosam E. Matar, Burton, A. Kim, Sadia Nafees, Clare Wilkinson, Lewis, R.A., Nafees, S., Williams, Nefyn, Burton, Anthony, Matar, HE, Fitzsimmons, D, Wilkinson, Clare, Sutton, Alex, Nafees, Sadia   +47 more
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USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Outcomes of C1–2 joint injections

, 2017
Christopher M Aiudi,1 W Michael Hooten,2 Rebecca A Sanders,2 James C Watson,2 Susan M Moeschler,2 Halena M Gazelka,2 Bryan C Hoelzer,2 Jason S Eldrige,2 Wenchun Qu,3 Tim J Lamer2 1Mayo Clinic School of Medicine, 2Division of Pain Medicine, Department of ...
Watson JC, Gazelka HM, Hoelzer BC, Hooten WM, Lamer TJ, Aiudi CM, Eldrige JS, Moeschler SM, Qu W, Sanders RA   +9 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Shortterm results of treatment of tennis elbow with antiinflammatory drugs alone or in combination with local injection of a corticosteroid and anesthetic mixture

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: We compared the short-term results of anti-inflammatory drugs alone or in combination with local injection of a corticosteroid and anesthetic mixture in the treatment of tennis elbow.\r\nMethods: The study included 21 patients (12 males, 9 ...
Serdar Toker, Volkan Kilincoglu, Elif Aksakalli, Erim Gulcan, Korhan Ozkan   +4 more
doaj  

Pharmaceutical Care in Ontario

Journal of Medical Science, 2020
Pharmaceutical care is an integral part of global healthcare. Indeed, pharmacists are recognised as a primary point of care, providing many services to optimise the patient’s healthcare.
Jacqueline Dzionek
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effectiveness of Ultrasound Guided Intraarticular Injections with Lidocaine and Triamcinolone: A Retrospective Study of Primary Hip Injections [PDF]

Maya Jurgens, Tarandeep Sidhu, Amir A Jamali Department of Orthopedic Surgery, Joint Preservation Institute, Walnut Creek, CA, USACorrespondence: Amir A Jamali, Department of Orthopedic Surgery, Joint Preservation Institute, 100 N. Wiget Lane, Suite 200,
Jamali AA, Jurgens M, Sidhu T
core  

Ischaemic strokes from facial injections of dermal fillers: Clinico-radiological features and outcomes

Introduction: Ischaemic stroke is a severe complication of dermal filler injections that remains poorly described and understood. This study aims to characterise the clinical features and outcomes of patients who experience strokes following facial ...
Li-Houng Chen, You-Jiang Tan
core   +1 more source