Results 71 to 80 of about 1,490 (268)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Carbon Capture and Storage in Depleted Oil and Gas Reservoirs: The Viewpoint of Wellbore Injectivity

Energies
Recently, there has been a growing interest in utilizing depleted gas and oil reservoirs for carbon capture and storage. This interest arises from the fact that numerous reservoirs have either been depleted or necessitate enhanced oil and gas recovery ...
Reyhaneh Ghorbani Heidarabad, Kyuchul Shin   +1 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Evaluation of CO₂ Injectivity and Geological Storage Scenarios Using Nodal Analysis and Tubing Injectivity Index in a Depleted Gas Field in Malaysia

Energies
This study presents a CO2 injectivity analysis for the depleted gas field Z offshore Malaysia using nodal analysis and sensitivity analysis. Reservoir permeability was estimated from the appraisal well DST report, which recorded an absolute open flow ...
Yubin An, Sunil Kwon
doaj   +1 more source

Injectivity sets of the spherical mean operator with respect to the Bessel convolution [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
Let $C_\natural$ be the set of all even continuous functions on the real axis, $E$ be a non-empty set on $(0,+\infty)$, $\mathcal{R} f(x,t)$ be the spherical mean of the function $f\in C_\natural$ with center at the point $x\in E$ and radius $t>0 ...
Krasnoschekikh, Gleb Vitalievich, Volchkov, Vitaliy Vladimirovich   +1 more
doaj   +1 more source

Injectivity And Annihilators

Demonstratio Mathematica, 1990
The paper starts off with a characterization of the known concept of a biregular ring in terms of the complement left annihilator of a semiprime ring. A ring \(A\) is said to be a \(LIS\) ring if for any two right ideals \(I\), \(J\) of \(A\), the equality \(\ell(I\cap J)=\ell(I)+\ell(J)\) holds.
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Development of a ranking-based framework for saline aquifers for CO2 storage

Carbon Management
This study introduces a comprehensive ranking-based framework for evaluating saline aquifers. By integrating theoretical principles, data-driven models, and real-world datasets, the framework incorporates trapping mechanisms structural, residual ...
Pet Pakchotanon, Thotsaphon Chaianansutcharit, Paul Tivere Benjamin, Malcolm Wilson, Kruawun Jankaew, Ratthapon Noosri   +5 more
doaj   +1 more source