Results 81 to 90 of about 3,363,869 (253)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Injury Risk Estimation Expertise Assessing the ACL Injury Risk Estimation Quiz [PDF]

, 2015
Background: Available methods for screening anterior cruciate ligament (ACL) injury risk are effective but limited in application as they generally rely on expensive and time-consuming biomechanical movement analysis.
Ward , P., Wallace, Sean J., Durocher, John, Petushek, E., Petuchek, Erich J., John J. Durocher, Wallace, Sean, Myer, Gregory D., Gregory D. Myer, Edward T. Cokely, Ward, Paul, Cokely, E., Petushek, Erich J., Paul Ward, Cokely, Edward T., Erich J. Petushek, Sean J. Wallace, Myer , G., Wallace , S., Cokely, Edward, Durocher, J., Durocher, John J, Durocher, John J.   +22 more
core   +1 more source

Baseline level of interleukin-6 is associated with the risk of acute coronary syndrome development in SARS-CoV‐2 infection

BMC Cardiovascular Disorders
Background Acute coronary syndrome (ACS) is frequently reported in patients with coronavirus disease 2019 (COVID-19). Cytokine storm induced by interleukin-6 (IL-6) has been suggested to potentially cause myocardial injury in COVID-19.
Mohsen Sedighi, Mohammad Hasan Shahabi, Maryam Akbarpour, Alireza Amanollahi, Nader Tavakoli, Aydin Mohammad Valipour, Hamed Basir Ghafouri   +6 more
doaj   +1 more source

Effect of bilateral upper limb training after priming upper limb robot training on upper limb function in stroke patients with severe hemiplegia

Zhongguo kangfu lilun yu shijian
Objective To compare the effect between unilateral and bilateral upper limb training on motor function of severely hemiplegic upper limbs in subacute stroke patients after priming robot-assisted training.
HE Aiqun, LI Jingbo, LIU Hai'ou, SONG Qiushuang, HE Maoli, LIN Rumin   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Social autopsy for maternal and perinatal deaths in Bangladesh: a tool for community dialog and decision making

Public Health Reviews, 2018
Bangladesh has an established comprehensive death review system for tracking and reviewing maternal and perinatal deaths. This death review system, established in 2010, was initially known as the “Maternal and Perinatal Death Review (MPDR) System.” One ...
Animesh Biswas, Junnatul Ferdoush, Abu Sayeed Md Abdullah, Abdul Halim   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mapping reticulospinal drive across various muscles of the upper and lower extremities

Experimental Physiology
The reticulospinal (RS) system is a fundamental descending pathway involved in human movement control. However, the relative strength of RS projections across different muscles and its specific contributions to distinct movements are poorly understood ...
Antonia Maria Eilfort, Lennart Carlson Neumann, Linard Filli   +2 more
doaj   +1 more source