Results 171 to 180 of about 2,427 (262)

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

open access: yesAdvanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu   +7 more
wiley   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

open access: yesAdvanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu   +8 more
wiley   +1 more source

Parametric action of homomorphic image of modular group and it's application in image encryption. [PDF]

open access: yesSci Rep
Rafiq A   +7 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma   +12 more
wiley   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

open access: yesAdvanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen   +6 more
wiley   +1 more source

A chameleon AIEgen exhibiting six distinct yet tunable thermal and photoswitchable states. [PDF]

open access: yesNat Commun
He X   +9 more
europepmc   +1 more source

Unity Quantum Yield of High‐Entropy Quantum Dots Composited With Photonic Crystals for Information Encryption

open access: yesAdvanced Science, EarlyView.
This study first extends the high‐entropy concept to I‐III‐VI quantum dots (QDs) and synthesizes CZCrGSe/ZnSe/ZnS core/shell/shell QDs with a record photoluminescence quantum yield (PLQY) of 100%. Their ZnSe/ZnS double shell efficiently passivates defects and boosts structural stability.
Maoyuan Huang   +9 more
wiley   +1 more source

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