Results 121 to 130 of about 451,488 (358)

Flexibility within the middle ears of vertebrates [PDF]

, 2013
Introduction and aims: Tympanic middle ears have evolved multiple times independently among vertebrates, and share common features. We review flexibility within tympanic middle ears and consider its physiological and clinical implications.
Baird, Bell, Burda, Dahmann, Feenstra, Fleischer, Goode, Goode, Ingelstedt, Jørgensen, Kirikae, Kobrak, Larsen, Lenhardt, M J Mason, M R B Farr, Manley, Marquet, Mason, Mason, Mason, Mason, Mills, Narins, Nishihara, Pau, Rosowski, Schuknecht, Segall, Smith, Tideholm, Werner, Wever, Wever, Wever, Yamada, Özcan   +36 more
core   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner

Frontiers in Cellular Neuroscience, 2020
Cellular senescence has classically been associated with aging. Intriguingly, recent studies have also unraveled key roles for senescence in embryonic development, regeneration, and reprogramming.
Marta Magariños, Marta Magariños, Marta Magariños, Raquel Barajas-Azpeleta, Raquel Barajas-Azpeleta, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto, Maria R. Aburto, Maria R. Aburto   +9 more
doaj   +1 more source

3D Printed Ear Canal Model [PDF]

, 2017
A multi-material ear canal model was designed and created from CT scans of an actual patient. This ear canal model serves as a training model for trainees, surgeons and doctors to develop a better understanding of the anatomy and physiology of the ear ...
Ali, Ahmad, Hairston, Rosheena, Locks, Hunter   +2 more
core   +1 more source

Endogenous bone marrow stem cell mobilization in rats: Its potential role in homing and repair of damaged inner ear [PDF]

, 2015
The stem cells are widely used in the last few years in different fields of medicine, either by external transplantation or endogenous mobilization, most of these studies are still experimental on animals; few were tried on humans as in the spinal cord ...
Abdel-Salam, Seddik, Elbana, Ahmed M., Ibrahim, Mohamed, Morad, Ghada M., Omran, Ahmed A.   +4 more
core   +2 more sources

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Accurate Detection of Inner Ears in Head CTs Using a Deep Volume-to-Volume Regression Network with False Positive Suppression and a Shape-Based Constraint [PDF]

arXiv, 2018
Cochlear implants (CIs) are neural prosthetics which are used to treat patients with hearing loss. CIs use an array of electrodes which are surgically inserted into the cochlea to stimulate the auditory nerve endings. After surgery, CIs need to be programmed.
arxiv  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Hand bone conduction sound study by using the DSP Logger MX 300 [PDF]

Revista Argentina de Bioingenier\'ia 24 (2), 17-21, 2020, 2020
Bone conduction is the transmission of acoustic energy to the inner ear by different paths involving the bones of the skull. In this work, we use the path the hand provides in order to transmit the sound coming from the cell phone using Bluetooth system.
arxiv  

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source