Results 141 to 150 of about 451,488 (358)
Assessment of drug permeability through an ex vivo porcine round window membrane model
iScience, 2023 Summary: Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear.
Adele Moatti +9 more
doaj
Applications of Scanning Electron Microscopy and X-Ray Microanalysis in Inner Ear Pathology [PDF]
, 1985 Surface pathology of inner ear structures so far described in detail concern cochlear and vestibular hair cells and the stria vascularis. In man, surgical intervention into the inner ear is very uncommon and when performed is in general with the primary ...
Anniko, M. +3 more
core +1 more source
The development of the vertebrate inner ear
Mechanisms of Development, 1998 The inner ear is a complex sensory organ responsible for balance and sound detection in vertebrates. It originates from a transient embryonic structure, the otic vesicle, that contains all of the information to develop autonomously into the mature inner ear.
Miguel Torres, F. Giraldez
openaire +3 more sources
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Eph and ephrin signaling in the development of the central auditory system
Developmental Dynamics, Volume 252, Issue 1, Page 10-26, January 2023., 2023 Abstract Acoustic communication relies crucially on accurate interpretation of information about the intensity, frequency, timing, and location of diverse sound stimuli in the environment. To meet this demand, neurons along different levels of the auditory system form precisely organized neural circuits.
Jakub Krasewicz, Wei‐Ming Yu
wiley +1 more source
Modeling, applications and challenges of inner ear organoid
Smart MedicineMore than 6% of the world's population is suffering from hearing loss and balance disorders. The inner ear is the organ that senses sound and balance. Although inner ear disorders are common, there are limited ways to intervene and restore its sensory ...
Jieyu Qi +7 more
doaj +1 more source
A Reconstruction Model of the Right Middle and Inner Ear [PDF]
, 1915 J.S. Fraser, John Dickie
openalex +1 more source
Advanced Science, EarlyView.By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini +24 more
wiley +1 more source
Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems
Developmental Dynamics, Volume 252, Issue 1, Page 81-103, January 2023., 2023 Abstract Sensory neurons of the head are the ones that transmit the information about the external world to our brain for its processing. Axons from cranial sensory neurons sense different chemoattractant and chemorepulsive molecules during the journey and in the target tissue to establish the precise innervation with brain neurons and/or receptor ...
Gemma Nomdedeu‐Sancho, Berta Alsina
wiley +1 more source
Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation
Advanced Science, EarlyView.This study presents a novel porous drug‐loading coating for cochlear electrodes, utilizing MA‐PDMS infused with GelMA hydrogel containing dexamethasone and MXene nanoparticles. The coating enhances biocompatibility, enables sustained drug release, reduces fibrosis, and preserves residual hearing post‐CI.
Lei Ren +15 more
wiley +1 more source