Results 91 to 100 of about 212,226 (348)

Identification of MIMAS, a multifunctional mega-assembly integrating metabolic and respiratory biogenesis factors of mitochondria

Cell Reports
Summary: The mitochondrial inner membrane plays central roles in bioenergetics and metabolism and contains several established membrane protein complexes.
Patrick Horten, Kuo Song, Joshua Garlich, Robert Hardt, Lilia Colina-Tenorio, Susanne E. Horvath, Uwe Schulte, Bernd Fakler, Martin van der Laan, Thomas Becker, Rosemary A. Stuart, Nikolaus Pfanner, Heike Rampelt   +12 more
doaj   +1 more source

Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1[S]

Journal of Lipid Research, 2012
Mitochondrial cholesterol is maintained within a narrow range to regulate steroid and oxysterol synthesis and to ensure mitochondrial function. Mitochondria acquire cholesterol through several pathways from different cellular pools.
Barry E. Kennedy, Mark Charman, Barbara Karten   +2 more
doaj   +1 more source

Functional Analysis of Subunit e of the F\u3csub\u3e1\u3c/sub\u3eF\u3csub\u3eo\u3c/sub\u3e-ATP Synthase of the Yeast \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e: Importance of the N-Terminal Membrane Anchor Region [PDF]

, 2005
Mitochondrial F1Fo-ATP synthase complexes do not exist as physically independent entities but rather form dimeric and possibly oligomeric complexes in the inner mitochondrial membrane.
Brunner, Susanne, Dolan, Brigid M., Dunn, Cory D., Everard-Gigot, Valerie, Jensen, Robert E., Stuart, Rosemary A.   +5 more
core   +1 more source

Tim23 Links the Inner and Outer Mitochondrial Membranes [PDF]

Cell, 2000
Tim23, a key component of the mitochondrial preprotein translocase, is anchored in the inner membrane by its C-terminal domain and exposes an intermediate domain in the intermembrane space that functions as a presequence receptor. We show that the N-terminal domain of Tim23 is exposed on the surface of the outer membrane.
Donzeau, Mariel, Káldi, Krisztina, Adam, Alexander, Paschen, Stefan, Wanner, Gerhard, Guiard, Bernard, Bauer, Matthias F, Neupert, Walter, Brunner, Michael   +8 more
openaire   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A mechanistic view of mitochondrial death decision pores

Brazilian Journal of Medical and Biological Research, 2007
Mitochondria increase their outer and inner membrane permeability to solutes, protons and metabolites in response to a variety of extrinsic and intrinsic signaling events. The maintenance of cellular and intraorganelle ionic homeostasis, particularly for
J.E. Belizário, J. Alves, J.M. Occhiucci, M. Garay-Malpartida, A. Sesso   +4 more
doaj  

Setting the curve: the biophysical properties of lipids in mitochondrial form and function

Journal of Lipid Research
Mitochondrial membranes are defined by their diverse functions, complex geometries, and unique lipidomes. In the inner mitochondrial membrane, highly curved membrane folds known as cristae house the electron transport chain and are the primary sites of ...
Kailash Venkatraman, Christopher T. Lee, Itay Budin   +2 more
doaj   +1 more source

Mitochondrial protein import [PDF]

, 1994
The transport of nuclear-encoded proteins from the cytosol into mitochondria is mediated by targeting (signal) sequences present on precursor forms.
Neupert, Walter, Schwarz, Elisabeth
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]

, 2018
PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core   +2 more sources