Results 151 to 160 of about 212,226 (348)

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy. [PDF]

Sci Rep, 2023
Alula KM, Delgado-Deida Y, Callahan R, Till A, Underwood L, Thompson WE, Souza RF, Dassopoulos T, Onyiah J, Venuprasad K, Theiss AL.   +10 more
europepmc   +1 more source

Atomic structure of the mitochondrial inner membrane AAA+ protease YME1 reveals the mechanism of substrate processing [PDF]

, 2017
Cristina Puchades, Anthony J. Rampello, Mia Shin, Christopher J. Giuliano, R. Luke Wiseman, Steven E. Glynn, Gabriel C. Lander   +6 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane. [PDF]

EMBO J, 2021
Xu Y, Erdjument-Bromage H, Phoon CKL, Neubert TA, Ren M, Schlame M.   +5 more
europepmc   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy. [PDF]

J Biol Chem, 2022
Sun S, Hou H, Ma G, Ma Q, Li N, Zhang L, Dong C, Cao M, Tam KY, Ying Z, Wang H.   +10 more
europepmc   +1 more source

Isolation of Tryptic Fragment of Antigen From Mitochondrial Inner Membrane Proteins Reacting With Antimitochondrial Antibody in Sera of Patients With Primary Biliary Cirrhosis [PDF]

, 1990
Daisaku Muno, Eiki Kominami, Hideo Ishii, Koh Usui, Koji Saifuku, Yuji Sakakibara, Toshihiko Namihisa   +6 more
openalex   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane [PDF]

, 2012
Steven M. Claypool, Yavuz Oktay, Pinmanee Boontheung, Joseph A. Loo, Carla M. Koehler   +4 more
openalex   +1 more source