Results 11 to 20 of about 212,226 (348)
Sorting pathways of mitochondrial inner membrane proteins [PDF]
European Journal of Biochemistry, 1990 Two distinct pathways of sorting and assembly of nuclear-encoded mitochondrial inner membrane proteins are described. In the first pathway, precursor proteins that carry amino-terminal targeting signals are initially translocated via contact sites ...
Hartl, Franz-Ulrich +5 more
core +7 more sources
Consequences of Folding the Mitochondrial Inner Membrane [PDF]
Frontiers in Physiology, 2020 A fundamental first step in the evolution of eukaryotes was infolding of the chemiosmotic membrane of the endosymbiont. This allowed the proto-eukaryote to amplify ATP generation while constraining the volume dedicated to energy production.
Carmen A. Mannella
doaj +3 more sources
TMEM65 is a mitochondrial inner-membrane protein [PDF]
PeerJ, 2014 It has been reported that the expression of TMEM65 is regulated by steroid receptor RNA activator (SRA). To date, however, the localization and function of TMEM65 remained unknown. We analyzed the intracellular localization of TMEM65.
Naotaka Nishimura +3 more
doaj +4 more sources
PRKN regulates inner mitochondrial membrane PHB2 during mitophagy. [PDF]
Autophagy Rep, 2023 PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria and is tightly associated with neurodegenerative diseases, including Parkinson disease and amyotrophic lateral sclerosis.
Sun S +6 more
europepmc +4 more sources
Metalloproteases of the Inner Mitochondrial Membrane. [PDF]
Biochemistry, 2017 The inner mitochondrial membrane (IM) is among the most protein-rich cellular compartments. The metastable IM subproteome where the concentration of proteins is approaching oversaturation creates a challenging protein folding environment with a high probability of protein malfunction or aggregation.
Levytskyy RM +2 more
europepmc +4 more sources
Consequences of inner mitochondrial membrane protein misfolding. [PDF]
Mitochondrion, 2019 Proteins embedded in the inner mitochondrial membrane (IMM) perform essential cellular functions. Maintaining the folding state of these proteins is therefore of the utmost importance, and this is ensured by IMM chaperones and proteases that refold and degrade unassembled and misfolded proteins.
Coyne LP, Chen XJ.
europepmc +4 more sources
Mitochondrial inner membrane in hypothyroidism [PDF]
Archives of Biochemistry and Biophysics, 1976 Abstract Inner membrane vesicles obtained from the liver mitochondria of hypothyroid and normal rats were compared. In the vesicles from hypothyroid rats the rate of ATP synthesis at 30 °C is 35–50% less than the normal rate. The Arrhenius profile for phosphorylation by such vesicles lacks the discontinuity at 21 °C that is seen with vesicles from ...
Chen, Yii-Der Ida, Hoch, Frederic L.
openaire +3 more sources
Electrical homeostasis of the inner mitochondrial membrane potential
Physical BiologyAbstract The electric potential across the inner mitochondrial membrane must be maintained within certain bounds for the proper functioning of the cell. A feedback control mechanism for the homeostasis of this membrane potential is proposed whereby an increase in the electric field decreases the rate-limiting steps of the electron ...
Peyman Fahimi +3 more
openalex +4 more sources
Biogenesis of Mitochondrial Inner Membrane Proteins [PDF]
Journal of Biological Chemistry, 1999 The mitochondrial inner membrane of most organisms studied so far contains about a dozen proteins made by the mitochondrial genetic system and on the order of 10 proteins imported from the cytoplasm. This review briefly describes the two major pathways by which proteins made inside or outside the mitochondria are inserted into the inner membrane. These
K, Tokatlidis, G, Schatz
openaire +2 more sources
Plant Mitochondrial Inner Membrane Protein Insertion [PDF]
International Journal of Molecular Sciences, 2018 During the biogenesis of the mitochondrial inner membrane, most nuclear-encoded inner membrane proteins are laterally released into the membrane by the TIM23 and the TIM22 machinery during their import into mitochondria. A subset of nuclear-encoded mitochondrial inner membrane proteins and all the mitochondrial-encoded inner membrane proteins use the ...
Renuka Kolli, Jürgen Soll, Chris Carrie
openaire +4 more sources