Results 61 to 70 of about 212,226 (348)

Chemical Modification of the Inner Mitochondrial Membrane

Journal of Biological Chemistry, 1972
Abstract 1. Exposure of mitochondria and submitochondrial particles from bovine heart to [35S]diazobenzenesulfonate yielded information on the asymmetrical distribution of membrane components. Radioactive coupling factor 1 (ATPase) was isolated from submitochondrial particles and radioactive cytochrome c from mitochondria.
D L, Schneider, Y, Kagawa, E, Racker
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase

Cell Reports
Summary: Mitochondrial cytochrome c oxidase, complex IV (CIV) of the respiratory chain, is assembled in a modular fashion from mitochondrial as well as nuclear-encoded subunits, guided by numerous assembly factors.
Lilia Colina-Tenorio, Patrick Horten, Enzo Scifo, Susanne E. Horvath, Rhena F.U. Klar, Chantal Priesnitz, Fabian den Brave, Martin van der Laan, Thomas Becker, Kuo Song, Heike Rampelt   +10 more
doaj   +1 more source

The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria [PDF]

, 1987
The precursor of the mitochondrial inner membrane protein ADP/ATP carrier is cytoplasmically synthesized without an amino-terminal peptide extension. We constructed a truncated precursor lacking the 103 amino acids from the amino terminus (about a third ...
Hoeben, Peter, Neupert, Walter, Pfanner, Nikolaus, Tropschug, Maximilian   +3 more
core  

Successive translocation into and out of the mitochondrial matrix [PDF]

, 1987
We investigated the import and sorting pathways of cytochrome b2 and cytochrome c1, which are functionally located in the intermembrane space of mitochondria.
Alt, Appleby, Bradford, Böhni, Chen, Conboy, Daum, Dowhan, Duffaud, Eilers, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Gubler, Guiard, Hallermayer, Harmey, Hartl, Hartl, Hartl, Hauska, Hay, Hayashi, Horwich, Hurt, Hurt, Hurt, Kaput, Kolanski, Krieg, Laemmli, Lewin, Li, McAda, Miura, Ohashi, Pelham, Perara, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pratje, Riezmann, Rottier, Römisch, Sadler, Schatz, Schleyer, Schleyer, Schmidt, Schmidt, Schwaiger, Simon, Smeekens, Stueber, Talmadge, Teintze, van Loon, van Loon, van Loon, Voordouw, Zimmermann, Zwizinski   +67 more
core   +1 more source

Inner mitochondrial membrane compartmentalization: Dynamics across scales

The International Journal of Biochemistry & Cell Biology, 2020
Mitochondria are known as dynamic organelles that fuse and divide under the control of certain proteins. These dynamics are important to shape mitochondria, maintain a healthy mitochondrial population, and enable physiological adaptations, to name just a few key processes.
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy

Scientific Reports
The complex architecture and biochemistry of the inner mitochondrial membrane generate ultra-structures with different phospholipid and protein compositions, shapes, characteristics, and functions.
Benjamin Gottschalk, Zhanat Koshenov, Roland Malli, Wolfgang F. Graier   +3 more
doaj   +1 more source

Mitochondrial Membrane Dynamics—Functional Positioning of OPA1

Antioxidants, 2018
The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion.
Hakjoo Lee, Yisang Yoon
doaj   +1 more source

Intramitochondrial sorting of the precursor to yeast cytochrome c oxidase subunit Va. [PDF]

, 1993
We have continued our studies on the import pathway of the precursor to yeast cytochrome c oxidase subunit Va (pVa), a mitochondrial inner membrane protein.
Cumsky, MG, Miller, BR
core