Results 71 to 80 of about 212,226 (348)

Separate fusion of outer and inner mitochondrial membranes [PDF]

EMBO reports, 2005
Mitochondria are enveloped by two closely apposed boundary membranes with different properties and functions. It is known that they undergo fusion and fission, but it has remained unclear whether outer and inner membranes fuse simultaneously, coordinately or separately.
Florence, Malka, Olwenn, Guillery, Carmen, Cifuentes-Diaz, Emmanuelle, Guillou, Pascale, Belenguer, Anne, Lombès, Manuel, Rojo   +6 more
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions

Pharmacological Research
The impact of mitochondrial dysfunction on the pathogenesis of cardiovascular disease is increasing. However, the precise underlying mechanism remains unclear.
Abdallah Iddy Chaurembo, Na Xing, Francis Chanda, Yuan Li, Hui-juan Zhang, Li-dan Fu, Jian-yuan Huang, Yun-jing Xu, Wen-hui Deng, Hao-dong Cui, Xin-yue Tong, Chi Shu, Han-bin Lin, Kai-xuan Lin   +13 more
doaj   +1 more source

Stomatin-like protein 2 deficiency results in impaired mitochondrial translation. [PDF]

PLoS ONE, 2017
Mitochondria translate the RNAs for 13 core polypeptides of respiratory chain and ATP synthase complexes that are essential for the assembly and function of these complexes.
Panagiotis Mitsopoulos, Orsolya Lapohos, Woranontee Weraarpachai, Hana Antonicka, Yu-Han Chang, Joaquín Madrenas   +5 more
doaj   +1 more source

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion [PDF]

, 2009
Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria.
David C. Chan, J. Michael Mccaffery, Janet M. Shaw, Mariam Ghochani, Terrence G. Frey, Zhiyin Song   +5 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells

Frontiers in Oncology, 2022
Helicobacter pylori (H. pylori)-derived vacuolating cytotoxin A (VacA) causes damage to various organelles, including mitochondria, and induces autophagy and cell death.
Li Wang, Juan Yi, Xiao-Yang Yin, Jin-Xia Hou, Jing Chen, Bei Xie, Gang Chen, Qun-Feng Wang, Li-Na Wang, Xiao-Yuan Wang, Jing Sun, Lei-Ming Huo, Tuan-Jie Che, Hu-Lai Wei, Hu-Lai Wei   +14 more
doaj   +1 more source

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion [PDF]

, 2009
Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (mammals), respectively.
Rachel M. DeVay, Lenin Dominguez-Ramirez, Laura L. Lackner, Suzanne Hoppins, Henning Stahlberg, Jodi Nunnari, Cipolat, Crowther, Danino, Daum, Duvezin-Caubet, Esser, Frezza, Gasper, Gipson, Gipson, Gray, Griffin, Griparic, Herlan, Herlan, Hermann, Hoppins, Hoppins, Ingerman, Ishihara, Ishihara, Koshiba, Lassmann, Lévy, Longtine, Low, Martí-Renom, McGuffin, McQuibban, Meeusen, Meeusen, Meglei, Naylor, Pettersen, Quan, Ramachandran, Rapaport, Siegel, Sesaki, Song, Sperka-Gottlieb, Tovchigrechko, Wong, Zick, Zinser   +50 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Formation of Mitochondrial Outer Membrane Derived Protrusions and Vesicles in Arabidopsis thaliana. [PDF]

PLoS ONE, 2016
Mitochondria are dynamic organelles that have inner and outer membranes. In plants, the inner membrane has been well studied but relatively little is known about the outer membrane.
Akihiro Yamashita, Masaru Fujimoto, Kenta Katayama, Shohei Yamaoka, Nobuhiro Tsutsumi, Shin-Ichi Arimura   +5 more
doaj   +1 more source