Results 81 to 90 of about 212,226 (348)

Modeling the Effects of Calcium Overload on Mitochondrial Ultrastructural Remodeling

Applied Sciences, 2021
Mitochondrial cristae are dynamic invaginations of the inner membrane and play a key role in its metabolic capacity to produce ATP. Structural alterations caused by either genetic abnormalities or detrimental environmental factors impede mitochondrial ...
Jasiel O. Strubbe-Rivera, Jiahui Chen, Benjamin A. West, Kristin N. Parent, Guo-Wei Wei, Jason N. Bazil   +5 more
doaj   +1 more source

Distinct steps in the import of ADP/ATP carrier into mitochondria [PDF]

, 1987
Transport of the precursor to the ADP/ATP carrier from the cytosol into the mitochondrial inner membrane was resolved into several consecutive steps. The precursor protein was trapped at distinct stages of the import pathway and subsequently chased to ...
Neupert, Walter, Pfanner, Nikolaus
core  

An amphitropic cAMP-binding protein in yeast mitochondria [PDF]

, 1989
: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol.
Bandlow W., Baranska J., Blok M., Brugge J., Burn P., Burn P., Cascales S. C., Cobon G. S., Cobon G. S., Cornell R., Courtneidge S. A., Cross G. A. M., Dils R. R., Dygas A., Gillfillan A. M., Guarnieri M., Hixson C. S., Hostetler K. Y., Jelsema C. L., Kraft A. S., Lassing I., Lassing I., Low M. G., Megli F. M., Meyer R. K., Muller G., Muller G., Muller G., Muller G., Nishizuka Y., Pelech S. L., Radika R., Rodel G., Rotman A., Schmidt M. F. G., Sefton B. M., Sleight R., Terce F., Towbin H., Wirtz K. W. A., Wirtz K. W. A., Wojtczak L., Yaffe M., Zborowski J.   +43 more
core   +3 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments

BMC Biology, 2020
Background The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane.
Heike Rampelt, Iva Sucec, Beate Bersch, Patrick Horten, Inge Perschil, Jean-Claude Martinou, Martin van der Laan, Nils Wiedemann, Paul Schanda, Nikolaus Pfanner   +9 more
doaj   +1 more source

Mitochondrial Permeability Transition

Cells, 2022
The mitochondrial permeability transition (PT) is a phenomenon that can be broadly defined as an increase in the permeability of the mitochondrial inner membrane [...]
Paolo Bernardi, Evgeny Pavlov
doaj   +1 more source

Import pathways of precursor proteins into mitochondria [PDF]

, 1988
The precursor of porin, a mitochondrial outer membrane protein, competes for the import of precursors destined for the three other mitochondrial compartments, including the Fe/S protein of the bc1- complex (intermembrane space), the ADP/ATP carrier ...
Neupert, Walter, Pfaller, Rupert, Pfanner, Nikolaus, Rassow, Joachim, Steger, Heinrich F.   +4 more
core  

Purification of the head-pieces of the elementary particles from beef heart mitochondria: their morphological structure and enzymatic activity [PDF]

, 1968
1. In order to obtain direct evidence for the enzymatic identification of the head-pieces of the elementary particles in the inner mitochondrial membrane, the head-pieces were detached by sonication from the isolated inner membrane of beef heart ...
Inohara, R., Koshiba, K., Oda, T., Yamamoto, G.   +3 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Biogenesis of mitochondrial β‐barrel membrane proteins

FEBS Open Bio
β‐barrel membrane proteins in the mitochondrial outer membrane are crucial for mediating the metabolite exchange between the cytosol and the mitochondrial intermembrane space. In addition, the β‐barrel membrane protein subunit Tom40 of the translocase of
Iniyan Ganesan, Jon V. Busto, Nikolaus Pfanner, Nils Wiedemann   +3 more
doaj   +1 more source