Results 191 to 200 of about 3,326,595 (262)

The role of inner nuclear membrane protein emerin in myogenesis. [PDF]

FASEB J
Marano N, Holaska JM.
europepmc   +1 more source

Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity. [PDF]

Mol Biol Cell, 2021
Flagg MP, Wangeline MA, Holland SR, Duttke SH, Benner C, Neal S, Hampton RY.   +6 more
europepmc   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex. [PDF]

Nat Commun
Ji Z, Siu WS, Dueñas ME, Müller L, Trost M, Carvalho P.   +5 more
europepmc   +1 more source

SUN4 is a spermatid type II inner nuclear membrane protein that forms heteromeric assemblies with SUN3 and interacts with lamin B3.

J Cell Sci, 2023
Thoma H, Grünewald L, Braune S, Pasch E, Alsheimer M.   +4 more
europepmc   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Substrate stiffness-dependent regulation of the SRF−Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin

Journal of Cell Science, 2017
M. Willer, Christopher W. Carroll
semanticscholar   +1 more source

The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity. [PDF]

Nat Commun
Li W, Liao Y, Liu Z, Niu L, Huang J, Jia Y, Xu R, Guan S, Liang Z, Li Y, Wu H, Zhu S, Tan L, Yu F, Wang Z, Sun L, Zhao D, Kong W, Fu Y.   +18 more
europepmc   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

The Pea Inner Nuclear Membrane SUN Domain Protein Modulates Plant (a)biotic Stress Responses by Regulating Nuclear Dynamics. [PDF]

Mol Plant Pathol
Sharma A, Mukherjee S, Verma A, Aryan A, Chandran D.   +4 more
europepmc   +1 more source