Results 81 to 90 of about 2,902 (158)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

A LEADER program szerepe a helyi önkormányzatok nemzetközi együttműködésének támogatásában

Tér és Társadalom
Az Európai Unióban a több, mint három évtizedes múltra visszatekintő LEADER program mindmáig egy olyan sajátos fejlesztési módszer, amelyben a place-based (helyalapú), alulról felfele építkező szemlélet a vállalkozások és civil szervezetek mellett a ...
István Finta
doaj   +1 more source

Comparison of computed tomographic, radiographic and anatomical dorsal hoof wall measurements

Equine Veterinary Education, EarlyView.
Summary Background No comparison of radiographic and computed tomographic (CT) dorsal hoof wall (DHW) thickness and DHW to the palmar length of the distal phalanx (DHWDP) ratio has been published. Radiographic measurements obtained with and without radiodense markers on the DHW have not been compared.
S.‐M. Obitayo, D. Pollard, L. Szabó, A. Nagy   +3 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

Risk Factors and Clinical Severity in Chronic Venous Disease: A New Look

International Journal of Dermatology, EarlyView.
Genetic factors, such as gender and positive family history, were associated with the occurrence of mild‐stage disease (CEAP C1–3). Obesity, lack of exercise, and working more than 8 h in a sitting or standing position are strongly associated with severe venous disease (CEAP C4–6).
Éva Badak, Eszter A. Janka, Patrícia Ari, Edina Bodnár, Krisztina Varga, László Virág, Éva Szabó   +6 more
wiley   +1 more source

How to optimise tournament draws: The case of the FIFA World Cup

International Transactions in Operational Research, EarlyView.
Abstract The organisers of major sports competitions use different policies with respect to constraints in the group draw. Our paper aims to rationalise these choices by analysing the trade‐off between attractiveness (the number of games played by teams from the same geographic zone) and fairness (the departure of the draw mechanism from a uniform ...
László Csató
wiley   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

The Experience of Care in People With Palliative Needs and Their Families: A Qualitative Metasynthesis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To synthesise and reinterpret qualitative evidence on how people with palliative care needs and their family caregivers experience the care process. Background Palliative care aims to provide holistic, person‐ and family‐centred care.
Ana Gil Méndez, Caterina Checa Jiménez, Ingrid Bullich Marín, Laura Navarrete Reyes, Carolina Watson Badia, Nina Granel Gimenez, Lídia Ribera Barberan, Mireia Subirana Casacuberta, Juan M. Leyva‐Moral   +8 more
wiley   +1 more source