Results 31 to 40 of about 557,025 (268)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Association of bioimpedance‐derived parameters with pulse wave velocity: Phase angle, extracellular to intracellular water ratio, and body cell mass

Physiological Reports
This study investigated the association between parameters derived from bioelectrical impedance spectroscopy (BIS) and arterial stiffness, as measured using carotid–femoral pulse wave velocity (cfPWV) and brachial‐ankle pulse wave velocity (baPWV) pulse ...
Yujiro Asano, Motohiko Miyachi, Hinako Nanri, Haruka Murakami, Yuko Gando, Takashi Nakagata, Tsukasa Yoshida, Tomohiro Okura, Yosuke Yamada   +8 more
doaj   +1 more source

Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial

Physiological Reports, 2022
Postdiagnosis physical activity is associated with improved cancer outcomes, but biological mechanisms mediating anticancer effects remain unclear. Recent findings suggest that physiological adaptations to acute exercise comprise potential anticancer ...
Sissal Sigmundsdóttir Djurhuus, Tim Schauer, Casper Simonsen, Birgitte Grønkær Toft, Adina Ruth Deborah Jensen, Janine Terra Erler, Martin Andreas Røder, Pernille Hojman, Klaus Brasso, Jesper Frank Christensen   +9 more
doaj   +1 more source

Productivity and offshoring innovative activities [PDF]

Economics of Innovation and New Technology, 2016
ABSTRACTRecent studies suggest that firms may gain from global sourcing of innovative activities. Yet, only a small number of firms offshore their R&D, design, and engineering tasks. To explain this selection pattern, this paper examines the heterogeneity in total factor productivity among a large group of European firms. The results suggest that those
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Essays on Innovative Activity and the Protection of Innovations [PDF]

, 2019
This dissertation looks at three widely accepted assumptions about how the patent system works: patent documents disclose inventions; this disclosure happens quickly, and patent owners are able to enforce patents. The first chapter estimates the effect of stronger trade secret protection on the number of patented innovations.
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cooperation in innovation activities: The importance of partners

Research Policy, 2010
This paper analyses the importance of cooperation partners for the development of innovation activities. We contribute to the literature on cooperation in innovation activities that seeks to identify the characteristics differentiating cooperative from non-cooperative firms by proposing a different approach to this problem.
de Faria, Pedro, Lima, Francisco, Santos, Rui   +2 more
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effect of a 1-year intervention comprising brief counselling sessions and low-dose physical activity recommendations in Japanese adults, and retention of the effect at 2 years: a randomized trial

BMC Sports Science, Medicine and Rehabilitation, 2021
Background In an effort to increase people’s adherence to active lifestyles, contemporary physical activity (PA) guidelines now include low-dose PA. Methods PA was evaluated in 583 participants of the Nutritional and Physical Activity Intervention Study (
Julien Tripette, Yuko Gando, Haruka Murakami, Ryoko Kawakami, Kumpei Tanisawa, Harumi Ohno, Kana Konishi, Michiya Tanimoto, Noriko Tanaka, Hiroshi Kawano, Kenta Yamamoto, Akie Morishita, Motoyuki Iemitsu, Kiyoshi Sanada, Nobuyuki Miyatake, Motohiko Miyachi   +15 more
doaj   +1 more source