Results 41 to 50 of about 557,025 (268)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Contextual Variation in External and Internal Workloads across the Competitive Season of a Collegiate Women’s Soccer Team

Sports, 2021
As sports technology has continued to develop, monitoring athlete workloads, performance, and recovery has demonstrated boundless benefits for athlete and team success.
Lauren E. Rentz, William Guy Hornsby, Wesley J. Gawel, Bobby G. Rawls, Jad Ramadan, Scott M. Galster   +5 more
doaj   +1 more source

Innovative activity and barriers to entry [PDF]

European Economic Review, 1977
Abstract The short-run effects of potential competition on innovative input decisions are studied for an innovating firm realizing that by increasing the magnitude of its efforts it may enlarge its temporary monopoly position. Additional protection from new competition is viewed as resulting from to the innovator exogenous barriers to rivals' entry ...
openaire   +1 more source

The Role of Obstacles to Innovation on Innovative Activities: An Empirical Analysis [PDF]

, 2018
We study the effect of different types of barriers to innovation (financial, demand, knowledge, market, cooperation, and regulatory barriers) on firm level innovation inputs and outputs. Using a pooled sample of three Chilean innovation surveys, based on an instrumental variables approach, we find that the probability of generating innovation outcomes ...
Zahler, Andrés, Goya, Daniel, Caamaño, Matías   +2 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Protein-rich food intake frequency score and muscle mass, strength, muscle-specific strength or physical performance in Japanese older women: a cross-sectional study

BMC Geriatrics
Background Sarcopenia, defined as age-related muscle loss, has significant implications on the physical performance and health of older adults. An adequate dietary protein intake plays a crucial role in maintaining muscle mass and function. In Japan, the
Yui Nakayama, Keiichi Yokoyama, Ai Moriyasu, Mika Kimura, Tsukasa Yoshida, Hisamine Kobayashi, Misaka Kimura, Yosuke Yamada   +7 more
doaj   +1 more source

Rising Threats and Evolving Trends: Five Years of Urinary Tract Infection Prevalence in a Portuguese Hospital

Clinics and Practice
Background/Objective: Urinary tract infections (UTIs) are a significant public health concern worldwide, yet longitudinal data from Portuguese hospital settings remain limited.
Francisco José Barbas Rodrigues, Patrícia Coelho, Sónia Mateus, Miguel Castelo-Branco   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

“Active Mathematics”—A Classroom-Based Physical Active Learning Intervention in an Elementary School: An Experimental Pilot Study

Education Sciences
This experimental pilot study aimed to compare the amount of physical activity (PA) of children in a second-year class of an elementary school that had a mathematics class while performing PA, based on playful math games, with children that had a ...
Liliana Ramos, Vera Simões, Susana Franco   +2 more
doaj   +1 more source