Results 41 to 50 of about 1,996,956 (313)

Innovation Systems in the Terms of Schumpeterian Crea-tive Destruction [PDF]

, 2016
‘Creative destruction\u27 is one of the most important analytical tools, taking into consideration both the economic and sociological characteristics of capitalist society.
Ciborowski, R. (Robert)
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Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Persistence and ability in the innovation decisions [PDF]

, 2003
The main concern of this paper is to analyse the complementarities between the decisions to carry out both product and process innovations. We also try to identify the main determinants of the innovation activity as well as to separate the experience ...
Labeaga, José M., Martínez Ros, Ester
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Challenges of open innovation: the paradox of firm investment in open-source software [PDF]

, 2006
Open innovation is a powerful framework encompassing the generation, capture, and employment of intellectual property at the firm level. We identify three fundamental challenges for firms in applying the concept of open innovation: finding creative ways ...
Brandenburger A.M., Campbell-Kelly M., Chandler A.D., Chesbrough H.W., Chesbrough H.W., Conant J., Freedman D.H., Glaser B., Hars A., Jaffe A.B., Kaplan J., Katz M.L., Lawler E.E., Lerner J., McKusick K., Moore G.A., Ouchi W.G., Perens B., Shapiro C., Smith D.K., Tennenhouse D., Valimaki M., von Hippel E., West J.   +23 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Protein-rich food intake frequency score and muscle mass, strength, muscle-specific strength or physical performance in Japanese older women: a cross-sectional study

BMC Geriatrics
Background Sarcopenia, defined as age-related muscle loss, has significant implications on the physical performance and health of older adults. An adequate dietary protein intake plays a crucial role in maintaining muscle mass and function. In Japan, the
Yui Nakayama, Keiichi Yokoyama, Ai Moriyasu, Mika Kimura, Tsukasa Yoshida, Hisamine Kobayashi, Misaka Kimura, Yosuke Yamada   +7 more
doaj   +1 more source

Rising Threats and Evolving Trends: Five Years of Urinary Tract Infection Prevalence in a Portuguese Hospital

Clinics and Practice
Background/Objective: Urinary tract infections (UTIs) are a significant public health concern worldwide, yet longitudinal data from Portuguese hospital settings remain limited.
Francisco José Barbas Rodrigues, Patrícia Coelho, Sónia Mateus, Miguel Castelo-Branco   +3 more
doaj   +1 more source

Social Entrepreneurs and Innovation for the Unemployment [PDF]

, 2019
This research explored the social entrepreneurship factors to reduce the rate of unemployment in North Sumatra Indonesia. Social entrepreneurship is built through four main elements, namely social value, civil society, innovation, and economic activity ...
Sari, A. I. (Ade)
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