Results 51 to 60 of about 1,996,956 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

“Active Mathematics”—A Classroom-Based Physical Active Learning Intervention in an Elementary School: An Experimental Pilot Study

Education Sciences
This experimental pilot study aimed to compare the amount of physical activity (PA) of children in a second-year class of an elementary school that had a mathematics class while performing PA, based on playful math games, with children that had a ...
Liliana Ramos, Vera Simões, Susana Franco   +2 more
doaj   +1 more source

Innovation in the Public Sector [PDF]

, 2012
Innovation is something that is new, capable of being implemented, and has a beneficial impact. It is not an event or activity; it is a concept, process, practice, and capability that defines successful organizations.
Serrat, Olivier
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Crossing the digital frontier: are older adults ready for virtual reality workouts?

Frontiers in Public Health
In the dynamic web of our digital age, virtual reality (VR) is crystallizing as a promising medium for promoting physical activity in older adults, overcoming age-old barriers.
André Ramalho, André Ramalho, Pedro Duarte-Mendes, Pedro Duarte-Mendes, Rui Paulo, Rui Paulo, João Serrano, João Serrano, João Petrica, João Petrica   +9 more
doaj   +1 more source

THE SYSTEM OF INNOVATION ENVIRONMENT MANAGEMENT: REGIONAL ASPECT

Вестник Российского экономического университета имени Г. В. Плеханова, 2018
The article describes ways of calculating economic efficiency of innovation. It shows parameters characterizing the level of innovation activity development at the present stage.
Aleksandr A. Gretchenko, Olga G. Demenko, Irina V. Gorokhova   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Relationship between bioelectrical impedance–derived muscle quality and physical activity, sedentary behavior, or sleep using compositional data analysis (CoDA)

Scientific Reports
The association between exercise behaviors—including physical activity (PA), light-intensity PA (LPA), moderate-to-vigorous-intensity PA (MVPA), sedentary behavior (SB), and sleep—and muscle quality remains unclear.
Yujiro Asano, Motohiko Miyachi, Hinako Nanri, Haruka Murakami, Yuko Gando, Takashi Nakagata, Tsukasa Yoshida, Tomohiro Okura, Yosuke Yamada   +8 more
doaj   +1 more source

Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity

Scientific Reports, 2017
Metagenomic analysis based on the 16S rRNA gene is generally performed to examine the diversity and abundance of commensal bacteria in feces, which is now recognized to be associated with human health and diseases.
Koji Hosomi, Harumi Ohno, Haruka Murakami, Yayoi Natsume-Kitatani, Kumpei Tanisawa, Soichiro Hirata, Hidehiko Suzuki, Takahiro Nagatake, Tomomi Nishino, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa   +11 more
doaj   +1 more source

Low muscle mass, malnutrition, sarcopenia, and associations with survival in adults with cancer in the UK Biobank cohort

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Low muscle mass (MM) is a common component of cancer‐related malnutrition and sarcopenia, conditions that are all independently associated with an increased risk of mortality.
Nicole Kiss, Carla M. Prado, Robin M. Daly, Linda Denehy, Lara Edbrooke, Brenton J. Baguley, Steve F. Fraser, Abbas Khosravi, Gavin Abbott   +8 more
doaj   +1 more source