Results 61 to 70 of about 170,506 (262)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
VikalpaTechnology innovation and adoption are key economic imperatives for growth in India’s economy, and especially in the healthcare sector. As an example of firm innovation adoption, this study explores the adoption of web accessibility standards by small ...
Krishna Jayakar, Smeeta Mishra
doaj +1 more source
Frontiers in CommunicationCommunication and innovation perception play interconnected roles in shaping farmers’ adoption of IoT-based smart farming technologies. This study examines how communication strategies and institutional support influence innovation perception and ...
Sumardjo +7 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Modelling innovation adoption spreading in complex networks
Applied Network ScienceInnovation adoption pattern has been found to be influenced by the underlying social network structure and its constituent entities. In this paper, we model innovation diffusion considering (1) the role of network structures in dictating the spread of ...
Jing-Lin Duanmu, Wei Koong Chai
doaj +1 more source
Reconceptualising e-business performance measurement using an innovation adoption framework
, 2012 Purpose – Previous empirical research into the performance measurement of exemplary e-businesses has pointed to a lack of progress in developing distinctive performance metrics for e-business and a failure to adopt best practice in performance management.
Barnes, D. +3 more
core +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
The diffusion/adoption of innovation in the internal market [PDF]
The main aim of the present study is to analyze the drivers of innovation adoption by (i) developing proper measures able to proxy for innovation adoption and internal market regulations, (ii) identifying the channels through which innovation adoption ...
Fabio Manca +4 more
core
Understanding Innovation Adoption: Effects of Orientation, Pressure and Control on Adoption Intentions [PDF]
, 2012 We develop and test a theoretically-based integrative framework of key proximal factors (orientation, pressure, and control) that helps to explain the effects of more general factors (the organisation's strategy, structure, and environment) on intentions
Murray, Jennifer +19 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source