Results 41 to 50 of about 124,389 (260)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Impact of corporate actions on the parameters of selected innovation diffusion models

Engineering Management in Production and Services
The study aims to identify relationships between organisational actions supporting Kaizen-based improvement initiatives and the parameters of selected innovation diffusion models.
Wysocki Kamil, Wiśniewski Zbigniew, Lota Aleksandra   +2 more
doaj   +1 more source

Multi-Level Networks of Management Accounting Innovation and Financial Distress [PDF]

فصلنامه بورس اوراق بهادار
Accordingly, this study aims to examine the role of multi-level networks in the dissemination of management accounting innovation on financial distress. The research method is mixed, comprising qualitative (fuzzy Delphi technique, interpretive structural
mohammad namazi, Pedram Azizi
doaj   +1 more source

Are farmer perceptions among significant determinants of adoption of agricultural diversity in Malawi? A case of Lilongwe district

Journal of Agriculture and Rural Development in the Tropics and Subtropics, 2020
Agricultural diversity can strengthen resilience of livelihood of farmers to climate change and market uncertainties while, potentially at the same time, offering better dietary and nutritional prospects for households. Adoption of agricultural diversity
Paul Fatch, Charles Masangano, Judith F. M. Kamoto, Irmgard Jordan, Thomas Hilger, Isaac Mambo, Alexander Kalimbira, Ernst-August Nuppenau   +7 more
doaj   +1 more source

Toward AI-designed innovation diffusion policies using agent-based simulations and reinforcement learning: The case of digital tool adoption in agriculture

Frontiers in Applied Mathematics and Statistics, 2023
In this paper, we tackle innovation diffusion from the perspective of an institution which aims to encourage the adoption of a new product (i.e., an innovation) with mostly social rather than individual benefits.
Meritxell Vinyals, Regis Sabbadin, Stéphane Couture, Loïc Sadou, Rallou Thomopoulos, Kevin Chapuis, Baptiste Lesquoy, Baptiste Lesquoy, Patrick Taillandier, Patrick Taillandier, Patrick Taillandier   +10 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

THE ROLE OF PROFESSIONAL LEADERSHIP IN DIFFUSION AGRICULTURAL INNOVATION IN SULAIMANI GOVERNORATE-KURDISTAN REGION-IRAQ

Zanco Journal of Pure and Applied Sciences
The main objective of this research is to identify the role of agricultural professional leadership in the diffusion of agricultural innovation. In addition, it seeks to rank the main fields of this leadership role in innovation diffusion and to analyze
Soz Loqman Faroq , Tahir Mohamad layeeq   +1 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source