Results 31 to 40 of about 36,782 (261)

The supply side of innovation diffusion - A UK SME broadband adoption perspective [PDF]

, 2011
Recent research suggests that the majority of the Small and medium sized enterprises (SMEs) e-business research focusses primarily on studying innovation diffusion within the SMEs themselves with limited research into the supply-side of innovation ...
Oni, O, Papazafeiropoulou, A
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Are farmer perceptions among significant determinants of adoption of agricultural diversity in Malawi? A case of Lilongwe district

Journal of Agriculture and Rural Development in the Tropics and Subtropics, 2020
Agricultural diversity can strengthen resilience of livelihood of farmers to climate change and market uncertainties while, potentially at the same time, offering better dietary and nutritional prospects for households. Adoption of agricultural diversity
Paul Fatch, Charles Masangano, Judith F. M. Kamoto, Irmgard Jordan, Thomas Hilger, Isaac Mambo, Alexander Kalimbira, Ernst-August Nuppenau   +7 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Random Lasers as Social Processes Simulators

Entropy, 2023
In this work, we suggest a quantum-like simulator concept to study social processes related to the solution of NP-hard problems. The simulator is based on the solaser model recently proposed by us in the framework of information cascade growth and echo ...
Alexander Alodjants, Peter Zacharenko, Dmitry Tsarev, Anna Avdyushina, Mariya Nikitina, Andrey Khrennikov, Alexander Boukhanovsky   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

THE ROLE OF PROFESSIONAL LEADERSHIP IN DIFFUSION AGRICULTURAL INNOVATION IN SULAIMANI GOVERNORATE-KURDISTAN REGION-IRAQ

Zanco Journal of Pure and Applied Sciences
The main objective of this research is to identify the role of agricultural professional leadership in the diffusion of agricultural innovation. In addition, it seeks to rank the main fields of this leadership role in innovation diffusion and to analyze
Soz Loqman Faroq , Tahir Mohamad layeeq   +1 more
doaj   +1 more source

Multi-Level Networks of Management Accounting Innovation and Financial Distress [PDF]

فصلنامه بورس اوراق بهادار
Accordingly, this study aims to examine the role of multi-level networks in the dissemination of management accounting innovation on financial distress. The research method is mixed, comprising qualitative (fuzzy Delphi technique, interpretive structural
mohammad namazi, Pedram Azizi
doaj   +1 more source