Results 51 to 60 of about 923,769 (294)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Measuring the Capacity of Organizations Innovation ‒ Major Process of Innovation Management

Amfiteatru Economic, 2015
The article approaches the problem of companies’ success in today’s economic context, characterized by a generalized market with increasing competitive and client requirements.
Dorin Maier, Livia Anastasiu, Roxana Sârbu , Thorsten Eidenmüller   +3 more
doaj  

Public Service Innovation and Evaluation Indicators

Journal of Technology Management & Innovation, 2013
This paper analyzes innovation in public services with emphasis on the application of evaluation indicators. It considers the clean development mechanism (CDM) projects developed in the Bandeirantes and São João landfills, both located in the city of São
Silvia Cruz, Sônia Paulino
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

THE STRATEGY OF THE STATE CORPORATION DEVELOPMENT – ECONOMIC GROWTH IN REGIONS AND ECONOMY SECURITY IN RUSSIA

Модернизация, инновация, развитие, 2015
On June 30, 2015 has come into force the Federal Law of theRussian Federation(№ 488-FL): “On the industrial Policy in theRussian Federation”. The law requires the innovation Production. At the same time, from the whole spectrum of the strategic documents
V. V. Simonova, O. O. Smirnova
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Assessing overall network structure in regional innovation policies: a case study of cluster policy in the West Midlands in the UK [PDF]

, 2013
Revisiting the theoretical roots of the key concepts of “embeddedness” and “networks” that underpin many recent regional innovation polices, this paper strives to achieve a more systematic understanding of the overall network structure of geographic ...
He, Shaowei, MacNeill, Stewart, Wang, Jinmin   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

2010 State New Economy Index [PDF]

, 2010
Measures states' economic structures on twenty-six indicators of their competitiveness in the New Economy: the prominence of knowledge jobs, globalization, economic dynamism, transformation to a digital economy, and technological innovation ...

core