Results 41 to 50 of about 638,921 (315)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Administrative SciencesThis study develops and validates an innovation management framework based on the integration of dynamic capabilities and multidimensional innovation process factors.
Sidney de Lima Pinto +3 more
doaj +1 more source
Innovations in sectors in the industrial approach [PDF]
Scientific Journal of the Military University of Land Forces, 2019 The article presents the development of innovations from the perspective of specific sectors. Typologies of innovations in sectors have been indicated and the most important differences between them have been articulated. The article describes the sector
Adrian Golonka
doaj +1 more source
Innovation Management Practices in Production-Intensive Service Firms [PDF]
, 2015 Postprint version of the article.This paper posits that innovation management practices are contingent upon the type of industry, and examines the innovation management practices in a distinctive set of service firms: production-intensive service firms ...
Pedersen, Per Egil +3 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Specific features of management of IT-consulters innovative projects
Путеводитель предпринимателя, 2020 Authors shows the way of how to manage innovation projects in IT-development and consulting. In article the method of compilation and controlling portfolios of innovative projects as the part of enterprise management toolkit is given.
T. V. Kakatunova, E. I. Ivanova
doaj
المجلة الدولية للأداء الاقتصادي, 2023 This research sought to determine the strength and nature of relationship between innovation capability and the application of sustainable development pillars.
Rayane REZAK +2 more
doaj
INNOVATIVE WAY OF DEVELOPMENTAS A MECHANISM OF NATIONAL ECONOMY MODERNIZATION
RUDN Journal of Public Administration, 2017 In this article the authors discuss the importance of innovation in national development, stands out a chain and effect relationship between the development of innovative and natural improvement of quality of production.
Svetlana A Pervoykina, Denis N Putimtsev
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source