Results 51 to 60 of about 638,921 (315)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Creating Global High-Performing Innovation Teams : Insights and Guidelines
, 2023 This study proposes a model, process and guidelines supporting the creation of global high-performing innovation teams. As global innovation work by teams has become more common, global companies conducting or aiming to conduct global innovation work ...
Johnsson, Mikael, Johnsson, Mikael,
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Journal of Open Innovation: Technology, Market and Complexity, 2022 : This study aims at identifying factors that facilitate the development of the capacity to generate innovations in a subsidiary of a multinational company.
Jeferson Lima Ribeiro +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Increased Variation or Higher Fences? Understanding Typological Evolution in Radical Innovation Management [PDF]
, 2016 This paper addresses a key issue of typological confusion in relation to radical innovation management research. Previous research has emphasized the need for a more parsimonious understanding of innovation typology, where a myriad of types are still ...
Santonen, Teemu +2 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
AI-driven innovation within the ICT sector
Smart Cities and Regional Development JournalInnovation is pivotal in the competitive landscape of the Information and Communication Technology (ICT) sector, particularly in the context of rapidly evolving technological advancements.
Erika GRABOCKA, Ervisa NDOKA
doaj +1 more source
INNOVATIONS: Managing innovation and innovators
College & Research Libraries News, 1987 INNOVATIONS: Managing innovation and ...
openaire +2 more sources
, 2019 Research on performance management (PM) of networks and radical innovation has largely developed along two isolated paths. On the one hand, a growing body of knowledge addresses the use of performance management systems in the context of networks ...
Gomes, Leonardo Augusto de Vasconcelos +5 more
core +1 more source