Results 61 to 70 of about 638,921 (315)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

ONTOLOGY INNOVATION MANAGEMENT

Вестник университета, 2016
In the article the ontology of innovation management, cognitive psychology of a manager are considered. There are expanded: special significance of language as a carrier of meaning and connection with practice; feedback philosophy of language, with ...
V. Ukolov, V. Kostryukov
doaj  

Towards Smart Public Administration: A TOE-Based Empirical Study of AI Chatbot Adoption in a Transitioning Government Context

Administrative Sciences
As governments pursue digital transformation to improve service delivery and administrative efficiency, AI chatbots have emerged as a promising innovation in smart public administration.
Mansur Samadovich Omonov, Yonghan Ahn
doaj   +1 more source

The impact of timing in innovation management

, 2016
An innovative idea launched in the wrong place at the wrong time may not deliver the outcomes hoped for. Based on 55 empirical studies, Bowen, Rostami and Steel (2010) suggest ‘timing is everything’ if innovation is to enhance organisational performance,
O'Loughlin, Andrew, Beckett, Ronald
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Measuring the Capacity of Organizations Innovation ‒ Major Process of Innovation Management

Amfiteatru Economic, 2015
The article approaches the problem of companies’ success in today’s economic context, characterized by a generalized market with increasing competitive and client requirements.
Dorin Maier, Livia Anastasiu, Roxana Sârbu , Thorsten Eidenmüller   +3 more
doaj  

Manageability of Technical Innovation through Technical Property Rights [PDF]

International Journal of Management, Knowledge and Learning, 2016
The term innovation is used in many respects and has been evolving over the last decades. This paper mainly focusses on managing technical innovation and differentiates this kind of innovation from others.
Michael Horeth
doaj  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Emerging Scientific Field Detection Using Citation Networks and Topic Models—A Case Study of the Nanocarbon Field

Applied System Innovation, 2020
In fields with high science linkage, such as the nanocarbon field, trends in academic papers are particularly important for identifying future technological trends. The use of the number of citations allows us to predict the qualitative trends on a paper-
Hajime Sasaki, Bunshi Fugetsu, Ichiro Sakata   +2 more
doaj   +1 more source