Results 51 to 60 of about 2,234,276 (312)

Innovation Offshoring, Institutional Context and Innovation Performance: A Meta‐Analysis [PDF]

Journal of Management Studies, 2018
AbstractInnovation offshoring (IO) has become a widespread management practice. Yet, evidence on the performance implications is inconsistent, and scattered across disciplines and contexts. We argue that the benefits firms can derive from IO depend on the institutional environment at home. Drawing on recent work on institutional theory in international
Rosenbusch, Nina, Gusenbauer, Michael, Hatak, Isabella, Fink, Matthias, Meyer, Klaus   +4 more
openaire   +6 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Innovation and firm performance [PDF]

In this paper, the current state of knowledge regarding the relation between innovation and firm performance is reviewed. The relationship is empirically tested. There is a special focus on small and medium-sized firms.
Jeroen de Jong, Mickey Folkeringa, Ron Kemp, Wubben   +3 more
core   +3 more sources

Modeling innovation: determinants of innovativeness and the impact of innovation on firm performance [PDF]

, 2008
The objective of this paper is to report on the method, analysis, and conclusions concerning two research questions formulated as: What are the determinants of innovation at firm level?” and “what is the impact of innovation on firm performance?” The ...
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy , Gunduz, Ulusoy , Gündüz   +7 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Studying early structural changes in SOS1 mediated KRAS activation mechanism

Current Research in Structural Biology
KRAS activation is known to be modulated by a guanine nucleotide exchange factor (GEF), namely, Son of Sevenless1 (SOS1). SOS1 facilitates the exchange of GDP to GTP thereby leading to activation of KRAS.
Kirti Bhadhadhara, Vinod Jani, Shruti Koulgi, Uddhavesh Sonavane, Rajendra Joshi   +4 more
doaj   +1 more source

Effect of minimal shoes and slope on vertical and leg stiffness during running

Journal of Sport and Health Science, 2015
Purpose: This study was designed to characterize and compare the vertical (kvert) and leg (kleg) stiffness measured during running in two different footwear conditions on negative, level, and positive slopes, using kinematic data only.
Thibault Lussiana, Kim Hébert-Losier, Laurent Mourot   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Study of diffuse scattering on facial surface using ray tracing approach

Scientific Reports
This study investigates the role of topographic attributes in light scattering and diffuse reflection on the skin surface, and diffuse transmission across the surface layer.
Po-Yen Lai, Ray Jia Hong Ng, Tatsuya Omotezako, Huizhe Liu, Wenjun Ding, Lim Jiun Yeu, Akira Matsubara   +6 more
doaj   +1 more source