Results 71 to 80 of about 23,707,889 (338)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Journal of NeuroEngineering and RehabilitationBackground Transcutaneous auricular vagus nerve stimulation (taVNS) paired with task-specific training has shown promise for improving upper-limb motor recovery after stroke but its effects on gait and balance remain unclear.
Ashraf N. H. Gerges +9 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Geofluids, 2022 The obvious anisotropy of layered rock mass prevents the built-in constitutive model of commercial simulation software from accurately describing the elastoplastic behavior of the rock mass.
Haoran Li +5 more
doaj +1 more source
Alliance Portfolios and Innovation Performance
Group & Organization Management, 2012 Whereas existing alliance portfolio studies mainly focus on the structure or management of alliance portfolios, we conceptually explore the connections between them. In particular, we formulate propositions, arguing that the formalization, centralization, and customization of alliance portfolio management moderate the relationship between the ...
Faems, D.L.M., Janssens, M., Neyens, I.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2018 My dissertation consists of three studies that connect innovation to performance in different ways. In my first study, I investigate how product quality, productivity, and customer satisfaction as intermediate performance measures capture information about current innovation activities and serve as leading indicators of future financial performance. My
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Connected innovation: an international comparative study that identifies mixed modes of innovation [PDF]
, 2011 This paper offers a new angle on innovation modalities by adopting a recently emerging approach towards identifying innovation typologies via exploratory data analysis techniques with the aim to tease out some underlying latent variables that represent ...
Frenz, Marion, Lambert, R.
core
Journal of Research in Education Sciences韓國早期之高齡政策係以「活力老化」（active ageing）為核心理念，強調透過經濟保障、健康促進與休閒文化建構等措施，提升退休老人之生活品質。然而，面對少子化情況加劇，以及人口快速老化與科技發展所引發之社會結構變遷，傳統高齡政策在回應高齡族群日益多元的需求與生活品質提升方面已顯不足。為回應此一轉變，韓國政府設立「首爾50Plus財團」（Seoul 50 Plus Foundation），並推動「50Plus政策」，致力於強化中老年職涯規劃、再就業能 力與社會參與等方面的支持機制 ...
朴東飛 Dong-Bee Park
doaj +1 more source