Results 81 to 90 of about 603,389 (312)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hex-Bar Deadlift as a Post Activation Performance Enhancement Warm-up Strategy for Golf Club Head Speed

International Journal of Strength and Conditioning
Club head speed (CHS) is a key determinate of golf ball carry distance. Greater carry distance correlates with greater skill. The aim of the present study is to investigate the acute effects of using the hex - bar deadlift as a post activation ...
Amanda Ehrlich, Parker Dietzel, Merrick Lincoln, Doug Smith, Quincy Johnson, Gena Guerin   +5 more
doaj   +1 more source

Exploring lean manufacturing practices' influence on process innovation performance

, 2018
Little is known about the effects of lean manufacturing practices on the process innovation performance of manufacturing organisations. This research aims to fill this gap and explore the aforementioned interdependency. A research framework consisting of
Vikas Kumar, Möldner, A.K., Garza-Reyes, J.A., Kumar, V., Kumar, Vikas, Jose Arturo Garza-Reyes, Garza-Reyes, Jose Arturo, Moeldner, Alexander, Alexander Kurt Möldner   +6 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Mergers & Acquisitions and Innovation Performance in the Telecommunications Equipment Industry [PDF]

In response to global market forces such as deregulation and globalization, technological change and digital convergence, the telecommunications in the 1990s witnessed an enormous worldwide round of Mergers & Acquisitions (M&A).
Tseveen Gantumur, Andreas Stephan
core   +2 more sources

Study Of The Level Of Health And Food Culture Among Students Of The Institute Of Physical And Sports Education ( University Of Chlef )

مجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضية
The objective of this study is to identify the level of food and health culture among students,A questionnaire was distributed to (281) students selected from three departments of the IEPS of the UHBC, namely the Department of Sports Training, Sports ...
Djaafri Asma, Guendez Ali
doaj   +1 more source

Connected innovation: an international comparative study that identifies mixed modes of innovation

, 2011
This paper offers a new angle on innovation modalities by adopting a recently emerging approach towards identifying innovation typologies via exploratory data analysis techniques with the aim to tease out some underlying latent variables that represent ...
Frenz, Marion, Lambert, R.
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Prediction method of TBM excavation axis deviation for small turning tunnels based on LSTM neural network

Meitan xuebao
During the construction of full face tunnel boring machine (TBM), due to the influence of geological environment, personnel operation, equipment itself and other factors, it is easy to cause large deviation between TBM boring route and design axis ...
Lijie DU, Hongda HAO, Qingwei LI, Yalei YANG, Weidong ZHANG, Jiayi LIU, Hongchao FENG   +6 more
doaj   +1 more source