Results 101 to 110 of about 9,827,909 (347)

Learning and innovative elements of strategy adoption rules expand cooperative network topologies [PDF]

, 2008
Cooperation plays a key role in the evolution of complex systems. However, the level of cooperation extensively varies with the topology of agent networks in the widely used models of repeated games. Here we show that cooperation remains rather stable by
A Feigel, A Szolnoki, A Traulsen, AL Barabasi, B Skyrms, C Hauert, Changshui Zhang, CJCH Watkins, CL Tang, DJ Watts, Enrico Scalas, F Fu, FC Santos, FC Santos, G Szabó, H Ebel, H Ohtsuki, I Derenyi, IA Kovacs, J Leskovec, J Vukov, JM McNamara, JM Pacheco, L Luthi, M Girvan, M Granovetter, M Kirschner, M Tan, M Tomassini, M Tomassini, MA Nowak, MA Nowak, MA Nowak, MD Cohen, MW Macy, MW Macy, Máté S. Szalay, N Masuda, P Csermely, P Holme, Peter Csermely, R Axelrod, R Durrett, RE Michod, RJ Aumann, RS Sutton, S Goyal, Shijun Wang, TW Sandholm, V Batagelj, Z Rong   +50 more
core   +5 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The Evolution of Open Innovation

Journal of Innovation Management, 2015
The discipline of Innovation is constantly evolving and we are now arguably at a strategic inflection point where a new paradigm of innovation is emerging.
Martin Curley
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Lisbon Agenda, Regional Innovation System and the New EU Cohesion Policy [PDF]

The EU’s cohesion policy should now be confluent with the goals of the Lisbon strategy by promoting growth and employment. In this context, the promotion of a concept called regional innovation system has recently become important in the EU for ...
Alina Schoenberg, Chang Woon Nam, Georg Wamser   +2 more
core  

Heroes and Cowards: Genealogy, Subjectivity and War in the Twenty-First Century

Genealogy, 2018
From the wars of Ancient Greece to the collapsing Islamic State in the present, the same, apparently timeless protagonists appear and their stories told and re-told: the heroes, cowards and other combatants.
Peter Lee
doaj   +1 more source

The Impact of Intergenerational Succession Intention on Family Firm's Innovation Strategy: Evidence from China. [PDF]

J Knowl Econ, 2022
Song S, Zhou L, Sindakis S, Aggarwal S, Chen C.   +4 more
europepmc   +1 more source

Product innovation and logistic optimization in a novel urban-type model [PDF]

We consider the strategic choice between product innovation and logistic optimization in a novel urban framework where consumers are distributed across the city and have different incomes depending on their location in the town. Depending on the relative
Luigi Filippini, Stefano Colombo
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source