Results 101 to 110 of about 437,094 (266)

Cost-benefit model for multi-generational high-technology products to compare sequential innovation strategy with quality strategy. [PDF]

PLoS One, 2021
Kim HJ, Jee SJ, Sohn SY.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Examining the adoption of technology-enhanced learning in universities and its effects on student performance, satisfaction, and motivation

Computers and Education Open
The integration of technology in Higher Education has witnessed substantial growth in recent years. While extensive research has explored the collective educational implications of Technology-Enhanced Learning (TEL) at universities, there remains an ...
Dr. Yan (Danni) Liang, Dr. Shujie Chen, Dr. Ruwan Abeysekera, Dr. Helen O'Sullivan, Dr Jeff Bray, Izzy Keevill-Savage   +5 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

AbGraftBERT: Enhancing Antibody Design Through Self-Grafting and Amino Acid-Based Perturbation of Pre- Trained Language Models

IEEE Access
Recent advancements in sequence-structure co-design have demonstrated the efficacy of integrating pre-trained language models (PLMs) with Graph Neural Network (GNN)-based modules for antigen-specific antibody design.
Ziheng Wang, Xinhe Li, Ying Xie, Zeyu Wen, Ruinian Jin, Hiroaki Takada, Ryoichi Nagatomi   +6 more
doaj   +1 more source

Core competencies for strategic grantmaking: lessons learned from the Innovation Strategy. [PDF]

Can J Public Health, 2021
Cook C, Bradley Dexter S.
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Creating value, not waste: Ecosystem collaboration for take-back

Cleaner Environmental Systems
A take-back system can reduce the usage of virgin natural resources by reusing discarded products. However, if actors in the take-back system treat the discarded products as waste, the reuse value potential is lost.
Torben Pedersen, Rasmus Jørgensen, Johan Lilja, Christer Hedlund   +3 more
doaj   +1 more source

Revisiting the Innovation Strategy performance measurement process: insights from practice. [PDF]

Can J Public Health, 2021
Boileau-Falardeau M, Farooqi S, O'Rourke C, Payne L.   +3 more
europepmc   +1 more source