Results 101 to 110 of about 438,479 (266)

Cost-benefit model for multi-generational high-technology products to compare sequential innovation strategy with quality strategy. [PDF]

PLoS One, 2021
Kim HJ, Jee SJ, Sohn SY.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Examining the adoption of technology-enhanced learning in universities and its effects on student performance, satisfaction, and motivation

Computers and Education Open
The integration of technology in Higher Education has witnessed substantial growth in recent years. While extensive research has explored the collective educational implications of Technology-Enhanced Learning (TEL) at universities, there remains an ...
Dr. Yan (Danni) Liang, Dr. Shujie Chen, Dr. Ruwan Abeysekera, Dr. Helen O'Sullivan, Dr Jeff Bray, Izzy Keevill-Savage   +5 more
doaj   +1 more source

Core competencies for strategic grantmaking: lessons learned from the Innovation Strategy. [PDF]

Can J Public Health, 2021
Cook C, Bradley Dexter S.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

SOCIO‑ECONOMIC DRIVERS AND INSTITUTIONAL CHALLENGES OF TOBACCO CONTRACT FARMING PARTICIPATION IN SVOSVE COMMUNAL AREA, ZIMBABWE

Apstract: Applied Studies in Agribusiness and Commerce
Tobacco remains Zimbabwe's Leading agricultural export crop, increasingly produced under contract farming arrangements. While contract farming offers inputs, technical assistance and assured markets, concerns persist that benefits are skewed towards ...
Nyasha Nyakuchena, Joseph P. Musara, Emmanuel Mwakiwa   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Revisiting the Innovation Strategy performance measurement process: insights from practice. [PDF]

Can J Public Health, 2021
Boileau-Falardeau M, Farooqi S, O'Rourke C, Payne L.   +3 more
europepmc   +1 more source