Results 111 to 120 of about 9,827,909 (347)

Blockchain for Patient and HCP Data Rights Management: Lessons from an Enterprise Install

open access: yesBlockchain in Healthcare Today, 2018
Session Description: Privacy laws like GDPR and California Consumer Privacy Act (CCPA) have created a much more regulated environment in which enterprises need to operate in regards to consumer data permissions.
Dominique Hurley
doaj  

stBERT: A Pretrained Model for Spatial Domain Identification of Spatial Transcriptomics

open access: yesIEEE Access
Recent studies have shown that clustering latent variables, derived from autoencoders (AEs) through reconstruction tasks, is effective for identifying spatial domains of spatial transcriptomics (ST).
Ziheng Wang   +3 more
doaj   +1 more source

Roles of mutation rate and co-existence of multiple strategy updating rules in evolutionary prisoner's dilemma games

open access: yes, 2019
The emergence and maintenance of cooperation has attracted intensive scholarly interest and has been analysed within the framework of evolutionary game theory. The role of innovation, which introduces novel strategies into the population, is a relatively
Takesue, Hirofumi
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Digitalization and Organizational Climate for Well-Being in Small European Firms: Does Collaboration Matter?

open access: yesAdministrative Sciences
Despite growing interest in organizational well-being, digitalization, and collaboration, their interrelations remain insufficiently explored in the context of small enterprises.
Jelke Roorde Veltman   +1 more
doaj   +1 more source

Predicting Future High-Cost Schizophrenia Patients Using High-Dimensional Administrative Data

open access: yesFrontiers in Psychiatry, 2017
BackgroundThe burden of serious and persistent mental illness such as schizophrenia is substantial and requires health-care organizations to have adequate risk adjustment models to effectively allocate their resources to managing patients who are at the ...
Yajuan Wang   +6 more
doaj   +1 more source

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