Results 51 to 60 of about 1,908,628 (306)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A Holistic Approach to Incubator Strategies in the Entrepreneurial Support Ecosystem

M@n@gement, 2020
This research employs ecosystem and strategic fit theories to understand incubators’ relationships with other ecosystem actors by investigating the elaboration of specialization, diversification, and co-opetition strategies.
Christina Theodoraki
doaj   +1 more source

Rebiasing: Managing automatic biases over time

Frontiers in Psychology, 2022
Automatic preferences can influence a decision maker’s choice before any relevant or meaningful information is available. We account for this element of human cognition in a computational model of problem solving that involves active trial and error and ...
Aleksey Korniychuk, Eric Luis Uhlmann
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Brief Review of the Four-decade Evolution of Science Popularization in China

Cultures of Science, 2019
This article presents a brief review of the history, main achievements and challenges faced during the 40-year evolution of science popularization (SP) in China that began with the reform and opening up process.
Fujun Ren PhD
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Do product innovation-related activities affect downsizing decisions? An organizational efficiency perspective [PDF]

, 2017
Firms’ innovation strategy typically involves the need to shape organizational changes within work structures and routines, even those concerning employee downsizing decisions.
Estrella Ramón, Antonia, Jiménez Castillo, David, Magán Díaz, Amalia, Rondán Cataluña, Francisco Javier (Coordinador)   +3 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Economic Inequalities in Immunization Coverage Among One-Year-Olds and Coverage Gains from Closing the Inequality Gap in 10 Low- and Middle-Income Countries in the Western Pacific Region, 1994–2021

Vaccines
Background: Immunization coverage has increased substantially in the Western Pacific Region, saving millions of lives and supporting disease elimination efforts.
Ana Mendez-Lopez, Roland Dilipkumar Hensman, Shanlong Ding, Kidong Park   +3 more
doaj   +1 more source