Zhishi guanli luntan[Purpose/significance] This paper aims to explore the feasible path for the construction of data-driven science and technology think tanks under the background of new generation information technology based on Qian Xuesen's meta-synthetic thought, and to
Feixiang Sun, Hong Wu, Jie Gao
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The Impact of Intergenerational Succession Intention on Family Firm's Innovation Strategy: Evidence from China. [PDF]
J Knowl Econ, 2022 Song S +4 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Government regulation strategy, leading firms' innovation strategy, and following firms imitation strategy: An analysis based on evolutionary game theory. [PDF]
PLoS One, 2023 Zhang M, Huang Y, Jin Y, Bao Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Blockchain for Patient and HCP Data Rights Management: Lessons from an Enterprise Install
Blockchain in Healthcare Today, 2018 Session Description: Privacy laws like GDPR and California Consumer Privacy Act (CCPA) have created a much more regulated environment in which enterprises need to operate in regards to consumer data permissions.
Dominique Hurley
doaj
Collaborative Innovation Strategy of Supply Chain in the Context of MCU Domestic Substitution : A Differential Game Analysis. [PDF]
Comput Econ, 2023 Wang Y, Wen H, Hu Z, Zhang Y.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Measuring the Enterprise Green Innovation Strategy Decision-Making Quality: A Moderating-Mediating Model. [PDF]
Front Psychol, 2022 Feng J, Pan Y, Zhuang W.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source