Results 71 to 80 of about 1,908,628 (306)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Experiencing virtual reality for perspective-taking of blind and visually impaired learners
Educational Technology & SocietyUnderstanding blindness or imagining being blind can be challenging for individuals without visual impairments. One of the affordances of high-immersion virtual reality (VR) is its ability to build empathy and facilitate perspective-taking.
Tania Heap +2 more
doaj +1 more source
R&D cooperation between firms and universities: some empirical evidence from Belgian manufacturing. [PDF]
This paper presents an econometric analysis of firm and industry characteristics conducive to cooperation with universities, using Community Innovation Survey data for Belgium.
Cassiman, Bruno, Veugelers, Reinhilde
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Fostering continuous innovation in design with an integrated knowledge management approach
, 2011 In the global competition, companies are propelled by an immense pressure to innovate. The trend to produce more new knowledge-intensive products or services and the rapid progress of information technologies arouse huge interest on knowledge management ...
Caillaud, Emmanuel +3 more
core +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Innovative Strategies And Innovative Technologies.
, 2018 In the course of the research: the definition of "innovation potential" is given; normative and legal acts regulating innovative activity are summarized; the tendency to decrease in activity of innovative activity in Ukraine is revealed; foreign experience and the role of innovative strategies in increasing the competitiveness of products, enterprises,
Filyppova, Svitlana, Saadzhan, Valentyna
openaire +2 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
How to transfer discontinuous technology into radical innovation: Some evidence from three nanotech cases [PDF]
In this paper the focus is on the strategy formulation processes, specifically supportive methods and structures, which address various managerial issues concerning discontinuous technologies and radical innovation in the early phase of strategic ...
Herstatt, Cornelius +2 more
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Determining the factor structure of an integrated innovation model [PDF]
, 2009 This paper reports on elemental factor analyses of the innovativeness study in the Turkish manufacturing industry, drawing on a sample of 184 manufacturing firms.
Alpkan, Lutfihak +7 more
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