Results 91 to 100 of about 11,105,485 (312)

The technological innovation systems framework: Response to six criticisms

, 2015
The technological innovation systems framework (TIS) is widely used to study the emergence and growth of new technological fields and industries.
Markard, J., Jacobsson, Staffan,, Markard, J.,, Hekkert, M.,, Hekkert, M., Jacobsson, Staffan, Markard, Jochen, Hekkert, Marko   +7 more
core   +1 more source

Technological innovation systems in contexts : Conceptualizing contextual structures and interaction dynamics [PDF]

, 2015
This paper addresses interactions between technological innovation systems (TIS) and wider “context structures”. While TIS studies have always considered various kinds of contextual influences, we suggest that the TIS framework can be further ...
Sandén, Björn, Truffer, B.,, Jacobsson, Staffan,, Sandén, Björn,, Hekkert, M.,, Hekkert, M., Markard, Jochen, Truffer, B., Truffer, Bernhard,, Sandén, Björn A., Bergek, Anna,, Hekkert, Marko,, Markard, J., Truffer, Bernhard, Markard, J.,, Hekkert, Marko, Jacobsson, Staffan, Markard, Jochen,, Sand\ue9n, Bj\uf6rn, Bergek, Anna   +19 more
core   +1 more source

Nature-based innovation systems [PDF]

, 2020
Transitions literature regards technologies as critical components in shifting systems towards sustainability, which has informed the development of the technology-oriented Technological Innovation System (TIS) framework. The emerging discourse on nature-
van der Jagt, Alexander P.N., Dorst, Hade, Raven, Rob, Environmental Governance, Innovation Studies, Dynamics of Innovation Systems, Runhaar, Hens   +6 more
core   +1 more source

What is a Complex Innovation System? [PDF]

SSRN Electronic Journal, 2015
Innovation systems are sometimes referred to as complex systems, something that is intuitively understood but poorly defined. A complex system dynamically evolves in non-linear ways giving it unique properties that distinguish it from other systems. In particular, a common signature of complex systems is scale-invariant emergent properties.
openaire   +6 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Pequeñas y medianas empresas tecnológicas en México: distribución regional e inserción en cadenas globales de valor

Región y Sociedad, 2019
El objetivo de este artículo es presentar una caracterización de las pequeñas y medianas empresas tecnológicas mexicanas y analizar los mecanismos por los cuales se insertan en segmentos de alto valor agregado en cadenas globales de valor. La metodología
Óscar F. Contreras Montellano , Maciel García Fuentes   +1 more
doaj   +1 more source

Firms dealing with regulatory change: innovation and political influence strategies [PDF]

, 2014
Firm-level strategies, particularly political strategies, are overlooked in transition studies. Therefore, we study how car manufacturers combine and change their innovation and political influence strategies in response to a technology-forcing ...
Wesseling, Joeri, Farla, Jacco, Hekkert, Marko, Innovation Studies, Dynamics of Innovation Systems   +4 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source