Results 81 to 90 of about 563,102 (265)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Innovation and Innovation Systems: relevance for the area of health - DOI: 10.3395/reciis.v1i1.41en

RECIIS, 2007
In the final decades of the 20th century, renewed attention began to be paid to processes of generating, diffusing and using knowledge. Various analytical and normative approaches have been developed to try and understand and guide these processes.
Helena M. M. Lastres, José Eduardo Cassiolato   +1 more
doaj  

Positioning in the Global Value Chain as a Sustainable Strategy: A Case Study in a Mature Industry

Administrative Sciences, 2014
As a result of the development of new industrialized countries, such as Brazil, China and other Southern Asian economies, as well as a globalized economy, traditional competitive paradigms based on advantages associated with costs and quality ...
Jose Albors-Garrigos, Blanca de Miguel Molina, Maria de Miguel Molina   +2 more
doaj   +1 more source

A Framework to Assess the Citation Performance of Complex Innovation Systems. [PDF]

Front Res Metr Anal, 2021
Ronda-Pupo GA.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Assessing the Origins, Evolution and Prospects of National Innovation Systems. [PDF]

J Knowl Econ, 2022
López-Rubio P, Roig-Tierno N, Mas-Verdú F.   +2 more
europepmc   +1 more source

A Systemic Approach to Innovation

, 2002
The context of this chapter is set by the contemporary transition from an industrial to a knowledge-based economy. OECD (1996a) has documented the way in which the knowledge-based economy of learning individuals, organisations and economies is emerging out of the machine-based economy that determined advanced economies in most of the time in the 20th ...
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Assessing climate change mitigation and adaptation strategies and agricultural innovation systems in the Niger Delta. [PDF]

GeoJournal, 2023
Ikehi ME, Ifeanyieze FO, Onu FM, Ejiofor TE, Nwankwo CU.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source