Results 61 to 70 of about 597,924 (217)

Learning for the Knowledge Society

Apstract: Applied Studies in Agribusiness and Commerce, 2007
With sustained use and creation of knowledge in the centre of the economic development process, an economy essentially becomes a Knowledge Economy. A Knowledge Economy (KE) is one that utilizes knowledge as the key engine of economic growth.
Ivana Tichá
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Towards a Triple Helix based efficiency index of innovation systems. [PDF]

Scientometrics, 2022
Jovanović M, Savić G, Cai Y, Levi-Jakšić M.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

SUSTAINABLE LIFESTYLES AND INNOVATION SYSTEMS: IMPLICATIONS FOR G20 AGENDA

Revista Tempo do Mundo
The Group of Twenty (G20) discussions have increasingly emphasized the importance of research, innovation, and the digital economy; however, the integration of innovation systems with climate response strategies, particularly sustainable lifestyles ...
Shailly Kedia, Manish Anand
doaj   +1 more source

Technological capabilities: strategic component of the competitiviness

Revista Facultad de Ingeniería Universidad de Antioquia, 2005
This paper presents an explanatory model for the dynamics of the competitiveness of companies and national economies. The model is based on approaches and theories about competitiveness, as well as new theories of growth, the theory of technological ...
Heberto Tapias García
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Innovation and Innovation Systems: relevance for the area of health - DOI: 10.3395/reciis.v1i1.41en

RECIIS, 2007
In the final decades of the 20th century, renewed attention began to be paid to processes of generating, diffusing and using knowledge. Various analytical and normative approaches have been developed to try and understand and guide these processes.
Helena M. M. Lastres, José Eduardo Cassiolato   +1 more
doaj  

A Framework to Assess the Citation Performance of Complex Innovation Systems. [PDF]

Front Res Metr Anal, 2021
Ronda-Pupo GA.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source