Results 71 to 80 of about 563,102 (265)

The Components of an Innovation System: A Conceptual Innovation System Framework [PDF]

Journal of Innovation and Business Best Practices, 2013
Innovation forms the basis of economic growth and development. The ＂innovation system＂ concept started receiving more attention in literature since the 1980s, but very few studies have attempted to explain the functioning of such a system. Therefore, the need arose to develop a model for an innovation system a gainst which specific innovation systems ...
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Learning for the Knowledge Society

Apstract: Applied Studies in Agribusiness and Commerce, 2007
With sustained use and creation of knowledge in the centre of the economic development process, an economy essentially becomes a Knowledge Economy. A Knowledge Economy (KE) is one that utilizes knowledge as the key engine of economic growth.
Ivana Tichá
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The role of trust and networks in developing Nicaraguan farmers’ agribusiness capacities

Journal of Agriculture and Rural Development in the Tropics and Subtropics, 2018
The main focus of most programmes in developing countries carried out by NGOs is to develop small-scale farmers’ capacities. One approach hereby is to use multi-stakeholder innovation systems, such as the ‘Nicaraguan Learning Alliance’ (NLA).
Dirk Hauke Landmann, Jean-Joseph Cadilhon   +1 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Technological capabilities: strategic component of the competitiviness

Revista Facultad de Ingeniería Universidad de Antioquia, 2005
This paper presents an explanatory model for the dynamics of the competitiveness of companies and national economies. The model is based on approaches and theories about competitiveness, as well as new theories of growth, the theory of technological ...
Heberto Tapias García
doaj   +1 more source

Towards a Triple Helix based efficiency index of innovation systems. [PDF]

Scientometrics, 2022
Jovanović M, Savić G, Cai Y, Levi-Jakšić M.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

SUSTAINABLE LIFESTYLES AND INNOVATION SYSTEMS: IMPLICATIONS FOR G20 AGENDA

Revista Tempo do Mundo
The Group of Twenty (G20) discussions have increasingly emphasized the importance of research, innovation, and the digital economy; however, the integration of innovation systems with climate response strategies, particularly sustainable lifestyles ...
Shailly Kedia, Manish Anand
doaj   +1 more source