Results 41 to 50 of about 850,120 (308)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Role of Aortic Geometry on Stroke Propensity based on Simulations of Patient-Specific Models

Scientific Reports, 2017
Stroke is a life threatening event that is expected to more than double over the next 40 years. Atrial fibrillation (AF) has been reported as a strong independent risk factor for stroke.
Hyo Won Choi, Tong Luo, Jose A. Navia, Ghassan S. Kassab   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Aligning femtech innovation With equity: a strategic framework for real world impact

Frontiers in Global Women's Health
Femtech is advancing rapidly as a field with the capacity to transform women's health by addressing prevailing inequities in diagnosis, care, and access. Despite systemic, structural, cultural, data, regulatory, and access barriers that have historically
Shirin Ashrafganjouei, Lindsay Eziashi, Muskaan Bhan, Roswitha Priscilla Verwer, Melissa Paola Mezzari   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Exposure to acute noxious heat evokes a cardiorespiratory shock response in humans

International Journal of Hyperthermia, 2022
Background: Noxious acute cold stimuli cause cold shock via the sympathetic nervous system. However, no studies have investigated respiratory “heat shock” in response to noxious acute heat stimuli (≥ 42 °C).
Nerijus Eimantas, Soneta Ivanove, Rima Solianik, Marius Brazaitis   +3 more
doaj   +1 more source

Innovating Firms and Aggregate Innovation [PDF]

Journal of Political Economy, 2002
We develop a parsimonious model of innovation to confront firmlevel evidence. It captures the dynamics of individual heterogeneous firms, describes the behavior of an industry with firm entry and exit, and delivers a general equilibrium model of technological change.
Klette, Tor Jakob, Kortum, Samuel
openaire   +6 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

ENTREPRENEURS CONFIDENCE IN INNOVATION AND THEIR INNOVATIVENESS

Economic Review, 2012
This article tests the hypothesis that entrepreneurs confidence in innovation has a positive effect on their innovativeness. The sample is 550 owner managers sampled from the population of owner managers in Iran in 2010, surveyed in the Global Entrepreneurship Monitor, GEM.
Nochian, Nastooh, Schøtt, Thomas
openaire   +4 more sources