Results 61 to 70 of about 312,450 (264)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Emergence and prospects of digital mediation in energy communities: ecosystem actors’ perspective

Energy, Sustainability and Society
Background Energy communities (ECs) hold out the promise of cleaner and more flexible energy systems through self-generation, demand response, and storage.
Khuram Shahzad, Sanna Tuomela, Jouni K. Juntunen, Hassan Yousaf   +3 more
doaj   +1 more source

Understanding Relationship: Maximizing the Effects of Science Coaching

Education Policy Analysis Archives, 2014
There is growing empirical evidence that instructional coaching can help teachers transfer their learning from professional trainings (e.g., new strategies) to classroom practice and that coaching promotes greater collaboration and reflection among ...
Ruth Anderson, Sue Feldman, Jim Minstrell   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Ultra-Wideband RF-Photonics Technology for Microwave Spectrometry

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
We describe an RF-photonic system architecture to measure microwave spectrum over a wide bandwidth with high resolution. The approach relies on the up-conversion of the electronic signal to the optical domain using a high-speed electro-optic modulator ...
Janusz Murakowski, Amjed Hallak, Andrew Mercante, Mathew J. Zablocki, Timothy Creazzo, Shouyuan Shi, Kevin Shreve, Matthew Gallion, Connor Creavin, Charles E. Harrity, Michael Gehl, Mehmet Ogut, Shannon T. Brown, Sidharth Misra, Pekka Kangaslahti, Eric Kittlaus, Dennis W. Prather   +16 more
doaj   +1 more source

The Innovation Innovation

, 2009
We seek explanation for how a species with our complex social systems could have arisen. We argue that an “innovation innovation” took place during hominin evolution that decoupled organizational change from a Darwinian evolutionary process and underlies the forms of social organization we find in human societies today.
D. Read, LANE, David Avra, S. van der Leeuw   +2 more
openaire   +3 more sources