Results 61 to 70 of about 1,803,748 (309)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress

Stem Cell Research & Therapy
Background This study explores the potential role of Thioredoxin-interacting protein (TXNIP) silencing in endothelial colony-forming cells (ECFCs) within the scope of age-related comorbidities and impaired vascular repair. We aim to elucidate the effects
Julia Jolibois, Alison Domingues, Divina El Hamaoui, Raphaël Awaida, Mathilde Berger-de-Gaillardo, Daniel Guérin, David M Smadja, Perrine Marquet-DeRougé, Isabelle Margaill, Elisa Rossi, Valérie Nivet-Antoine   +10 more
doaj   +1 more source

Optimizing Test and Treat in Malawi: health care worker perspectives on barriers and facilitators to ART initiation among HIV-infected clients who feel healthy

Global Health Action, 2020
Background: Test and Treat has been widely adopted throughout sub-Saharan Africa, whereby all HIV-positive individuals initiate antiretroviral therapy (ART) immediately upon diagnosis and continue for life. However, clients who feel healthy may delay ART
Kathryn Dovel, Khumbo Phiri, Misheck Mphande, Deborah Mindry, Esnart Sanudi, Mcdaphton Bellos, Risa M. Hoffman   +6 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

How to facilitate the implementation and diffusion of sustainable Product-Service Systems? Looking for synergies between strategic design and innovation sciences [PDF]

, 2010
Copyright @ 2010 Greenleaf PublishingEco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability. However the application of this concept is still very limited because eco-efficient PSS are intrinsically ...
Ceschin, F
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Multitrait genetic parameter estimates in a Tenebrio molitor reference population: high potential for breeding gains

Animal
To address multiple issues impacting the climate imbalance, insects, and in particular Tenebrio molitor, represent now a promising alternative for producing high-quality protein products with low environmental impact. As with any new species farmed on an
E. Sellem, K. Paul, A. Donkpegan, Q. Li, A. Masseron, A. Chauveau, F. Gagnepain-Germain, T. Lefebvre   +7 more
doaj   +1 more source

Work Organisation and Innovation [PDF]

, 2012
[Excerpt] Innovations in work organisation have the potential to optimise production processes in companies and improve employees’ overall experience of work.
Cox, Annette, Rickard, Catherine, Tamkin, Penny   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Comparison of personal and shared frameshift neoantigen vaccines in a mouse mammary cancer model

BMC Immunology, 2020
Background It is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging.
Milene Peterson, Sierra Nicole Murphy, John Lainson, Jian Zhang, Luhui Shen, Chris W. Diehnelt, Stephen Albert Johnston   +6 more
doaj   +1 more source