Results 141 to 150 of about 11,103,293 (250)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Innovation as a community-spanning process: strategies to handle path dependency. [PDF]

In this paper, we further develop and apply the notions of path creation and path dependency during technological innovation processes. The process of technological innovation is portrayed as an activity of spanning boundaries between and across ...
Bouwen, René, Debackere, Koenraad, Van Looy, Bart   +2 more
core  

Knowledge Translation Interventions for Youth Health Care Transitions: Protocol for a Realist Review. [PDF]

JMIR Res Protoc
MacIntyre G, Flynn R, Birnie KA, Boulos L, Gallant SM, Graham ID, Grant A, Gray M, Harvey G, Higgins A, Hilario CT, Kontak JC, McNeil DA, Munce S, Pidduck J, Scott SD, Toulany A, Cassidy CE.   +17 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Engaging tuberculosis-affected people in investment decisions: applying a people-centered design approach in Viet Nam. [PDF]

BMC Public Health
Forse R, Vu PT, Nghiem T, Vo LNQ, Codlin AJ, Pham NB, Huynh N, Nguyen TT, Vinh LQ, Ngan NTK, Thuy NT, Khanh PVP, Bang ND, Cross A, Wilson M, Lüneburg K, Cherney M, Silberzahn T, Dinh LV, Nguyen HB, Nguyen LH, Minh HDT, Nguyen KTM, Hua TT, Huh J, Annerstedt KS.   +25 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Design For Gathering People: Seven Planning Process

, 1993
152 hlm.; ill.; 30 ...
PROCESS ARCHITECTURE 113
core  

Exploring innovation landscapes: a national cross-sectional study of Swedish primary care from the viewpoint of primary care managers. [PDF]

BMC Health Serv Res
Samuelson S, Petersson EL, Björkelund C, Björk MP, Hange D, Östman M, Kylén SP, Svenningsson I.   +7 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Shifting logics of legitimation in the diffusion of complex innovations [PDF]

Legitimation and competition are two major forces moulding organizational field and the diffusion of innovations. While discursive legitimation provides "rational justifications" for innovations, competition may incite organizations to acquire effective ...
Stéphane Guérard, Ann Langley
core