Results 61 to 70 of about 484,838 (307)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Agglomeration economies, knowledge spillovers, technological diversity and spatial clustering of innovations. [PDF]

This paper explores the spatial patterns of innovative activities from an empirical perspective and with reference to the Italian case. Using patent and other economic data at the NUTS 3 level (provinces), it borrows methodology and techniques from ...
Stefano Breschi
core  

Agent modelling of cluster formation processes in regional economic systems [PDF]

, 2016
The subject matter of this research is the processes of the spontaneous clustering in the regional economy. The purpose is the development and approbation of the modeling algorithm of these processes.
Boush, G. D., Kulikova, О. М., Shelkov, I. К.   +2 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Le cluster innovant : conceptualisation et application territoriale

Cybergeo, 2011
Following the rediscovery of Alfred Marshall’s academic publications during the eighties, a widening number of research papers - mainly drafted in Europe and the United-States - concentrates on explaining the ins and outs of the spatial and relational ...
Divya Leducq, Bruno Lusso
doaj   +1 more source

Models of wave-function collapse, underlying theories, and experimental tests

, 2012
We describe the state of the art in preparing, manipulating and detecting coherent molecular matter. We focus on experimental methods for handling the quantum motion of compound systems from diatomic molecules to clusters or biomolecules.Molecular ...
Adler, S. L., Albert, D., Allen, L., Angelo Bassi, Arndt, M., Ashkin, A., Bell, J. S., Bell, J. S., Bell, J. S., Bohm, D., Breuer, H.-P., Bub, J., Christian, J., Deutsch, D., DeWitt, D. S., Dürr, D., Dürr, D., Feynman, R. P., Frenkel, A., Frenkel, A., Frenkel, A., Ghirardi, G., Ghirardi, G. C., Gikhman, I. I., Gisin, N., Goldin, G. A., Griffiths, R. B., Grishchuk, L. P., Hendrik Ulbricht, Holland, P. R., Joos, E., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Kinjalk Lochan, Landau, L. D., Lyth, D. H., Maudlin, T., Myrvold, W. C., Omnès, R., Omnès, R., Pearle, P., Pearle, P., Pearle, P., Percival, I. C., Rauch, H., Schilpp, P. A., Schlosshauer, M., Seema Satin, Singh, T. P., Tejinder P. Singh, von Neumann, J., Wheeler, J. A.   +54 more
core   +2 more sources

Silicon Pixel R&D for the CLIC Tracking Detector

, 2020
The physics aims at the proposed high-energy $e^+e^-$ collider CLIC pose challenging demands on the performance of the detector system. Precise hit-time tagging, an excellent spatial resolutions, and a low mass are required for the vertex and tracking ...
Kröger, Jens
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source